      Document 0096
 DOCN  DRG0096
 UNIQUE IDENTIFIER        DRG-0151
 NAME OF SUBSTANCE        SP-303T [FDA 120A]
 PROTOCOL ID NUMBERS      FDA 120A
 SECONDARY SOURCE ID      SP303T [FDA 120A]
 SECONDARY SOURCE ID      SP-303 [Antiviral Res 1994 Dec;25(3-4)]
 PHARMACOLOGICAL ACTION   MODE OF ACTION: SP-303 was found to have
                          antiviral activity against two strains of
                          type 1 herpes-type simplex virus, including a
                          thymidine-kinase-deficient strain, and a
                          strain of type 2 herpes simplex virus. The
                          50% effective concentrations (EC50's) were
                          1-2 microM. Acyclovir, which was run in
                          parallel, had values of 4-28 microM.
                          Surprisingly, the compound was inactive
                          against human cytomegalovirus. SP-303 was
                          also virucidal at 50 microM. Interferon was
                          not induced. The mode of antiviral action of
                          this biopolymer was through inhibition of
                          virus penetration into cells (EC50 = 2.1 +/-
                          0.2 microM). SP-303 also significantly
                          reduced lesion formation in a mouse vaginal
                          model when applied topically at 5-10%.
                          [Chemotherapy 1993 May-Jun;39(3)]
 DISEASES STUDIED/TREATED Treatment of herpes simplex virus lesions
                          [FDA 120A]
 CLASSIFICATION CODE      Antiviral [Chemotherapy 1993 May-Jun;39(3)]
 OTHER MAJOR USES         Under investigation in animal studies for
                          effect on influenza A virus; topical therapy
                          for herpes simplex virus infection [Antiviral
                          Res 1994 Dec;25(3-4)] [Antiviral Res 1993
                          May;21(1)]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: A natural plant flavonoid
                          polymer [Chemotherapy 1993 May-Jun;39(3)]
 CHEMICAL/PHYSICAL DATA   MOLECULAR WEIGHT: 2,100 daltons [Chemotherapy
                          1993 May-Jun;39(3)]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Topical. [FDA 120A]
 MANUFACTURERS            Shaman Pharmaceuticals Inc
 REFERENCES               Safrin S, McKinley G, McKeough M, Robinson D,
                          Spruance SL. Treatment of
                          acyclovir-unresponsive cutaneous herpes
                          simplex virus infection with topically
                          applied SP-303. Antiviral Res 1994
                          Dec;25(3-4):185-92.
 REFERENCES               Sidwell RW, Huffman JH, Moscon BJ, Warren RP.
                          Influenza virus-inhibitory effects of
                          intraperitoneally and aerosol-administered
                          SP-303, a plant flavonoid. Chemotherapy 1994
                          Jan-Feb;40(1):42-50.
 REFERENCES               Barnard DL, Huffman JH, Meyerson LR, Sidwell
                          RW. Mode of inhibition of respiratory
                          syncytial virus by a plant flavonoid, SP-303.
                          Chemotherapy 1993 May-Jun;39(3):212-7.
 REFERENCES               Barnard DL, Smee DF, Huffman JH, Meyerson LR,
                          Sidwell RW. Antiherpesvirus activity and mode
                          of action of SP-303, a novel plant flavonoid.
                          Chemotherapy 1993 May-Jun;39(3):203-11.
 REFERENCES               Gilbert BE, Wyde PR, Wilson SZ, Meyerson LR.
                          SP-303 small-particle aerosol treatment of
                          influenza A virus infection in mice and
                          respiratory syncytial virus infection in
                          cotton rats. Antiviral Res 1993
                          May;21(1):37-45.
 REFERENCES               Wyde PR, Ambrose MW, Meyerson LR, Gilbert BE.
                          The antiviral activity of SP-303, a natural
                          polyphenolic polymer, against respiratory
                          syncytial and parainfluenza type 3 viruses in
                          cotton rats. Antiviral Res 1993
                          Feb;20(2):145-54.
 ENTRY MONTH              9212
 LAST REVISION DATE       960404
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
