      Document 0065
 DOCN  DRG0065
 UNIQUE IDENTIFIER        DRG-0182
 NAME OF SUBSTANCE        RMP-7 [AmFAR Tx Dir 1995;7(4)]
 PROTOCOL ID NUMBERS      FDA 131A
 SECONDARY SOURCE ID      DRG
 PHARMACOLOGICAL ACTION   MODE OF ACTION: RMP-7 is believed to cause
                          increased cerebrovascular permeability by the
                          activation of B2 receptors on the vascular
                          endothelium. [J Pharmacol Exp Ther 1994
                          Oct;271(1)]
 DISEASES STUDIED/TREATED Treatment of cryptococcal meningitis [AmFAR
                          Tx Dir 1995;7(4)]
 CLASSIFICATION CODE      Antifungal [FDA 131A]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: A bradykinin analog with
                          the amino acid sequence:
                          Arg-Pro-Hyp-Gly-Thi-Ser-Pro-Tyr(Me)-
                          psi(CH2NH)-Arg [FDA 131A] [J Pharmacol Exp
                          Ther 1994 Oct;271(1)]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Intravenous injection.
                          [AmFAR Tx Dir 1993;6(4)]
 MANUFACTURERS            Alkermes, Incorporated
 REFERENCES               Elliott PJ, Mackic JB, Graney WF, Bartus RT,
                          Zlokovic BV. RMP-7, a bradykinin agonist,
                          increases permeability of blood-ocular
                          barriers in the guinea pig. Invest Ophthalmol
                          Vis Sci 1995 Nov;36(12):2542-7.
 REFERENCES               Straub JA, Akiyama A, Parmar P, Musso GF.
                          Chemical pathways of degradation of the
                          bradykinin analog, RMP-7. Pharm Res 1995
                          Feb;12(2):305-8.
 REFERENCES               Straub JA, Akiyama A, Parmar P. In vitro
                          plasma metabolism of RMP-7. Pharm Res 1994
                          Nov;11(11):1673-6.
 REFERENCES               Doctrow SR, Abelleira SM, Curry LA,
                          Heller-Harrison R, Kozarich JW, Malfroy B,
                          McCarroll LA, Morgan KG, Morrow AR, Musso GF,
                          et al. The bradykinin analog RMP-7 increases
                          intracellular free calcium levels in rat
                          brain microvascular endothelial cells. J
                          Pharmacol Exp Ther. 1994 Oct;271(1):229-37.
 REFERENCES               Inamura T, Nomura T, Bartus RT, Black KL.
                          Intracarotid infusion of RMP-7, a bradykinin
                          analog: a method for selective drug delivery
                          to brain tumors. J Neurosurg. 1994
                          Nov;81(5):752-8.
 ENTRY MONTH              9307
 LAST REVISION DATE       960411
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
