      Document 0044
 DOCN  DRG0044
 UNIQUE IDENTIFIER        DRG-0203
 NAME OF SUBSTANCE        Diethylhomospermine [AmFAR Tx Dir 1995;7(4)]
 REGISTRY NUMBER          119422-08-1
 STANDARD CHEMICAL NAME   1,4-Butanediamine,
                          N,N'-bis(4-(ethylamino)butyl)- [CHEMLINE]
 SYNONYMS                 N(1),N(14)-bis(ethyl)homospermine [MeSH]
 SYNONYMS                 BEHSpm [MeSH]
 SYNONYMS                 BE-4-4-4 [MeSH]
 SYNONYMS                 1,14-Bis(ethylamino)-5,10-diazatetradecane
                          [MeSH]
 SYNONYMS                 N(1),N(14)-diethylhomospermine [MeSH]
 SYNONYMS                 DEHSPM [MeSH]
 PROTOCOL ID NUMBERS      FDA 223A
 SECONDARY SOURCE ID      DRG
 PHARMACOLOGICAL ACTION   MODE OF ACTION: In a previous experiment to
                          determine the antiproliferative effects of
                          diethylhomospermine in human transitional
                          cell carcinoma lines, the drug suppressed the
                          activity of the biosynthetic enzymes
                          ornithine decarboxylase and
                          S-adenosylmethionine decarboxylase. The
                          substantial antiproliferative activity of
                          this polyamine analog was believed to result
                          from mechanisms other than polyamine
                          depletion. However, other experiments using
                          HeLa cells demonstrated that
                          diethylhomospermine depleted polyamines. [J
                          Urol 1993;150] [Biochemistry 1993;32]
 DISEASES STUDIED/TREATED Refractory AIDS-related diarrhea [AmFAR Tx
                          Dir 1995;7(4)]
 CLASSIFICATION CODE      Antidiarrheal [AmFAR Tx Dir 1995;7(4)]
 OTHER MAJOR USES         Inhibited growth of tumor cells in culture
                          [Biochemistry 1993 Vol 32]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: Synthetic polyamine analog
                          [AmFAR Tx Dir 1995;7(4)]
 CHEMICAL/PHYSICAL DATA   MOLECULAR FORMULA: C16H38N4 [CHEMLINE]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Intravenous. [FDA 223A]
 MANUFACTURERS            Gainesville Veterans Administration Medical
                          Center
 REFERENCES               Bergeron CJ, Basu HS, Marton LJ, Deen DF,
                          Pellarin M, Feuerstein BG. Two polyamine
                          analogs (BE-4-4-4 and BE-4-4-4-4) directly
                          affect growth, survival, and cell cycle
                          progression in two human brain tumor cell
                          lines. Cancer Chemother Pharmacol
                          1995;36(5):411-7.
 REFERENCES               Bergeron RJ, Wiegand J, Sninsky CA, Katovich
                          MJ. The impact of polyamine analogues on the
                          blood pressure of normotensive and
                          hypertensive rats. Clin Exp Hypertens 1995
                          Nov;17(8):1197-217.
 REFERENCES               Fernandez CO, Frydman B, Samejima K.
                          Interactions between polyamine analogs with
                          antiproliferative effects and tRNA: a 15N NMR
                          analysis. Cell Mol Biol (Noisy-le-grand) 1994
                          Nov;40(7):933-44.
 ENTRY MONTH              9403
 LAST REVISION DATE       960417
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
