      Document 0026
 DOCN  DRG0026
 UNIQUE IDENTIFIER        DRG-0221
 NAME OF SUBSTANCE        CI-O694 [NIAID 95 I-126]
 STANDARD CHEMICAL NAME   5-(Sulfamethoxazoyl)-glutaryl-dexamine [NIAID
                          95 I-126]
 SYNONYMS                 Sulfasim [NIAID 95 I-126]
 PROTOCOL ID NUMBERS      NIAID 95I-126
 SECONDARY SOURCE ID      DRG
 PHARMACOLOGICAL ACTION   MODE OF ACTION: Therapeutic suppression of
                          IgG antibody response to SMX, probably by
                          acting at the level of B cells with receptor
                          specificity for SMX. [NIAID 95 I-126]
 DISEASES STUDIED/TREATED Possible prevention or reversal of
                          sensitivity to SMX in patients with HIV
                          infection and SMX intolerance [NIAID 95
                          I-126]
 CLASSIFICATION CODE      Immunomodulator [NIAID 95 I-126]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: Dextran backbone to which
                          20-50 sulfamethoxazole (SMX) molecules are
                          covalently attached [NIAID 95 I-126]
 CHEMICAL/PHYSICAL DATA   MOLECULAR WEIGHT: 28 +/- 8 kg/mole [NIAID
                          SULFASIM]
 CHEMICAL/PHYSICAL DATA   SOLUBILITY: Readily soluble in water or
                          saline [NIAID 95 I-126]
 CHEMICAL/PHYSICAL DATA   PHYSICAL DESCRIPTION: Lyophilized powder
                          [NIAID 95 I-126]
 SUBSTANCE DELIVERY DATA  DOSAGE FORM: 120 mg vials. [NIAID 95 I-126]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Subcutaneous. [NIAID 95
                          I-126]
 SUBSTANCE DELIVERY DATA  STORAGE INSTRUCTIONS: Store at 2-8 C. [NIAID
                          95 I-126]
 MANUFACTURERS            Cortech Inc
 ENTRY MONTH              9505
 LAST REVISION DATE       951129
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
