      Document 0022
 DOCN  DRG0022
 UNIQUE IDENTIFIER        DRG-0225
 NAME OF SUBSTANCE        Clavulanate Potassium [USAN 1996]
 REGISTRY NUMBER          61177-45-5
 STANDARD CHEMICAL NAME   4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic
                          acid,
                          3-(2-hydroxyethylidene)-7-oxo-,monopotassium
                          salt, [2R-(2alpha,3Z,5alpha]- [USAN 1996]
 SYNONYMS                 Component of Augmentin (in combination with
                          amoxicillin trihydrate) [PDR 1995]
 SYNONYMS                 Potassium clavulanate [CHEMLINE]
 PROTOCOL ID NUMBERS      FDA 243A
 SECONDARY SOURCE ID      BRL 14151K [USAN 1996]
 PHARMACOLOGICAL ACTION   MODE OF ACTION: Clavulanic acid, which is
                          produced by fermentation of Streptomyces
                          clavuligerus, possesses the ability to
                          inactivate a wide variety of beta-lactamases
                          by blocking the active sites of these
                          enzymes. Clavulanic acid is particularly
                          active against the clinically important
                          plasmid mediated beta-lactamases frequently
                          responsible for transferred drug resistance
                          to penicillins and cephalosporins. It is
                          approximately 30% bound to human serum. [PDR
                          1995]
 DISEASES STUDIED/TREATED AIDS-associated sinusitis [FDA 243A]
 CLASSIFICATION CODE      Antibacterial [PDR 1995]
 CLASSIFICATION CODE      Beta-lactamase Inhibitor [USAN 1996]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: Potassium salt of
                          clavulanic acid, which is a beta-lactam
                          structurally related to the penicillins [PDR
                          1995]
 CHEMICAL/PHYSICAL DATA   MOLECULAR FORMULA: C8H8KN05 [USAN 1996]
 CHEMICAL/PHYSICAL DATA   MOLECULAR WEIGHT: 237.25 [USAN 1996]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Oral. [PDR 1995]
 MANUFACTURERS            Smith Kline Beecham
 ENTRY MONTH              9506
 LAST REVISION DATE       951129
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
