      Document 0021
 DOCN  DRG0021
 UNIQUE IDENTIFIER        DRG-0226
 NAME OF SUBSTANCE        OPC 14117 [CHEMLINE]
 REGISTRY NUMBER          103233-65-4
 STANDARD CHEMICAL NAME   1-Piperazineacetamide,
                          N-(2,3-dihydro-7hydroxy-2,2,4,6-tetramethyl-1-
                          H-iden-1-yl)-4 -(3-methoxphenyl)- [CHEMLINE]
 SYNONYMS                 OPC-14117 [MeSH]
 PROTOCOL ID NUMBERS      FDA 242A
 SECONDARY SOURCE ID      DRG
 PHARMACOLOGICAL ACTION   MODE OF ACTION: Has both a brain
                          function-activating effect and protective
                          effect against cerebral ischemia. Acts by
                          inhibiting oxygen free radicals. Oxygen free
                          radicals generated by leukocytes may
                          contribute to tissue injury after central
                          nervous system (CNS) focal ischemia or
                          trauma. In vitro studies using stimulated
                          polymorphonuclear (PMN) leukocytes and
                          monocytes demonstrated that OPC 14117
                          significantly reduces PMN hydrogen peroxide
                          production, with the 100 microM concentration
                          of the drug significantly more effective than
                          the 10 microM concentration. [J Neurol Sci
                          1992 May;109(1); MeSH]
 DISEASES STUDIED/TREATED HIV-related cognitive dysfunction [FDA 242A]
 CLASSIFICATION CODE      Antioxidant [CHEMLINE]
 CHEMICAL/PHYSICAL DATA   MOLECULAR FORMULA: C26H35N3O3 [CHEMLINE]
 SUBSTANCE DELIVERY DATA  DOSAGE FORM: 60 mg tablets. [FDA 242A]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Oral [FDA 242A]
 MANUFACTURERS            Otsuka America Pharmaceutical Inc
 REFERENCES               Fisher M and Arpano MM. Inhibition of
                          stimulated human leukocyte hydrogen peroxide
                          generation by a novel antioxidant, OPC-14117.
                          J Neurol Sci 1992 May;109(1):107-10.
 ENTRY MONTH              9507
 LAST REVISION DATE       951129
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
