      Document 0017
 DOCN  DRG0017
 UNIQUE IDENTIFIER        DRG-0230
 NAME OF SUBSTANCE        ALVAC-HIV MN120TMG (vCP205) [NIAID VEU 022]
 SYNONYMS                 ALVAC-HIV (vCP205) [NIAID VEU 022]
 PROTOCOL ID NUMBERS      NIAID VEU 022
 SECONDARY SOURCE ID      DRG
 PHARMACOLOGICAL ACTION   MODE OF ACTION: In vitro, has been shown to
                          stimulate CD8+ env-specific and gag-specific
                          cytotoxic T-lymphocyte (CTL) precursors
                          present in PBMCs derived from
                          HIV-seropositive patients. [NIAID VEU 022]
 DISEASES STUDIED/TREATED Prevention of HIV infection [NIAID VEU 022]
 CLASSIFICATION CODE      Vaccine [NIAID VEU 022]
 ADVERSE EFFECTS          Adverse effects include pain, soreness,
                          redness, and swelling at site of injection,
                          as well as fever, chills, rash, aches, pains,
                          nausea, headaches, and fatigue. [NIAID VEU
                          022]
 CONTRAINDICATIONS        Contraindicated in pregnant women. [NIAID VEU
                          022]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: Canarypox recombinant
                          vaccine that involves a complex antigen
                          consisting of HIV-1 MN gp120 plus the
                          transmembrane portion of HIV-1 LAI gp41 as
                          well as HIV-1 gag and protease [NIAID VEU
                          022]
 CHEMICAL/PHYSICAL DATA   PHYSICAL DESCRIPTION: Pale yellow lyophilized
                          product [NIAID VEU 022]
 CHEMICAL/PHYSICAL DATA   PHYSICAL DATA: pH 7.66 [NIAID VEU 022]
 SUBSTANCE DELIVERY DATA  DOSAGE FORM: Lyophilized product in vials
                          containing 580000 TCID50. [NIAID VEU 022]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Intramuscular. [NIAID VEU
                          022]
 SUBSTANCE DELIVERY DATA  STORAGE INSTRUCTIONS: Store at 3-5 C. Do not
                          freeze. [NIAID VEU 022]
 MANUFACTURERS            Pasteur Merieux Serums et Vaccins
 ENTRY MONTH              9509
 LAST REVISION DATE       951006
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
