      Document 0016
 DOCN  DRG0016
 UNIQUE IDENTIFIER        DRG-0231
 NAME OF SUBSTANCE        PCLUS [AIDS Therapies 1995 Sep]
 SYNONYMS                 Engineered peptide clusters [AIDS Therapies
                          1995 Sep]
 PROTOCOL ID NUMBERS      NCI 94 C-159
 SECONDARY SOURCE ID      DRG
 PHARMACOLOGICAL ACTION   MODE OF ACTION: Induction of cytotoxic T
                          lymphocytes and neutralizing antibodies. [J
                          Immunol 1994 Jan 15;152(2)]
 DISEASES STUDIED/TREATED Primary HIV infection [NCI 94 C-159]
 CLASSIFICATION CODE      Vaccine [AIDS Therapies 1995 Sep]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: Multiple peptide sequences
                          from the HIV-1 MN envelope protein that are
                          recognized by multiple human and murine major
                          histocompatibility complex ( MHC ) types.
                          [AIDS Therapies 1995 Sep]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: These sequences contain
                          peptide 18. The peptide clusters are held
                          together in Montanide Incomplete Seppic
                          Adjuvant ( ISA ) [AIDS Therapies 1995 Sep]
 MANUFACTURERS            Peninsula Labs
 REFERENCES               Shirai M, Pendleton CD, Ahlers J, Takeshita
                          T, Newman M, Berzofsky JA. Helper-cytotoxic T
                          lymphocyte (CTL) determinant linkage required
                          for priming of anti-HIV CD8+ CTL in vivo with
                          peptide vaccine constructs. J Immunol. 1994
                          Jan 15;152(2):549-56.
 REFERENCES               Ahlers JD, Pendleton CD, Dunlop N, Minassian
                          A, Nara PL, Berzofsky JA. Construction of an
                          HIV-1 peptide containing a multideterminant
                          helper peptide linked to a V3 loop peptide 18
                          inducing strong neutralizing antibody
                          responses in mice of multiple MHC haplotypes
                          after two immuniztions. J Immunol. 1993 Jun
                          15;150(12):5647-65.
 REFERENCES               Berzofsy JA, Pendleton CD, Clerici M, Ahlers
                          J, Lucey DR, Putney SD, Shearer GM.
                          Construction of peptides encompassing
                          multideterminant clusters of human
                          immunodeficiency virus envelope to induce in
                          vitro T cell responses in mice and humans of
                          multiple MHC types. J Clin Invest. 1991
                          Sep;88(3):876-84.
 ENTRY MONTH              9510
 LAST REVISION DATE       951102
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
