      Document 0013
 DOCN  DRG0013
 UNIQUE IDENTIFIER        DRG-0234
 NAME OF SUBSTANCE        ISIS 2922 [Int Conf AIDS 1994 Aug 7-12;10(2)]
 PROTOCOL ID NUMBERS      FDA 251A
 PROTOCOL ID NUMBERS      FDA 251B
 PROTOCOL ID NUMBERS      FDA 251C
 SECONDARY SOURCE ID      DRG
 DISEASES STUDIED/TREATED CMV retinitis [Int Conf AIDS 1994 Aug
                          7-12;10(2)]
 CLASSIFICATION CODE      Antiviral [MeSH]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: Phosphorothioate antisense
                          oligonucleotide [Int Conf AIDS 1994 Aug
                          7-12;10(2)]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Intravitreal [Int Conf AIDS
                          1994 Aug 7-12;10(2)]
 MANUFACTURERS            Isis Pharmaceuticals Inc
 REFERENCES               Azad RF, Brown-Driver V, Buckheit RW Jr,
                          Anderson KP. Antiviral activity of a
                          phosphorothioate oligonucleotide
                          complementary to human cytomegalovirus RNA
                          when used in combination with antiviral
                          nucleoside analogs. Antiviral Res. 1995
                          Oct;28(2):101-11.
 REFERENCES               Azad RF, Driver VB, Tanaka K, Crooke RM,
                          Anderson KP. Antiviral activity of a
                          phosphorothioate oligonucleotide
                          complementary to RNA of the human
                          cytomegalovirus major immediate-early region.
                          Antimicrob Agents Chemother 1993
                          Sep;37(9):1945-54.
 REFERENCES               Palestine AG, Cantrill HL, Luckie AP, Ai E.
                          Intravitreal treatment of CMV retinitis with
                          an antisense oligonucleotide, ISIS 2922. Int
                          Conf AIDS 1994 Aug 7-12;10(2):10 (abstract
                          no. 332B).
 ENTRY MONTH              9511
 LAST REVISION DATE       960412
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
