      Document 0011
 DOCN  DRG0011
 UNIQUE IDENTIFIER        DRG-0236
 NAME OF SUBSTANCE        Thioctic acid [USAN 1996]
 REGISTRY NUMBER          62-46-4
 STANDARD CHEMICAL NAME   1,2-Dithiolane-3-valeric acid [USAN 1996]
 SYNONYMS                 Biletan [Merck Index 1989]
 SYNONYMS                 Lipoicin [Merck Index 1989]
 SYNONYMS                 Thioctacid [Merck Index 1989]
 SYNONYMS                 Thioctan [Merck Index 1989]
 SYNONYMS                 Tioctan [Merck Index 1989]
 SYNONYMS                 alpha-Lipoic acid [CHEMLINE]
 SYNONYMS                 Lipoic acid [CHEMLINE]
 SYNONYMS                 Protogen A [Merck Index 1989]
 SYNONYMS                 1,2-Dithiolane-3-pentanoic acid [Merck Index
                          1989]
 PROTOCOL ID NUMBERS      FDA 250A
 SECONDARY SOURCE ID      2319-84-8 (sodium) [CHEMLINE]
 SECONDARY SOURCE ID      94599-85-6 (olamine) [CHEMLINE]
 PHARMACOLOGICAL ACTION   MODE OF ACTION: Enhances the free radical
                          scavenging mechanisms of vitamin E. Free
                          radicals can damage brain cells. [FDA 250A]
 DISEASES STUDIED/TREATED HIV-associated dementia [FDA 250A]
 CLASSIFICATION CODE      Antioxidant [Arzneimittelforschung 1993
                          Dec;43(12)]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: Enzymatic cofactor [FDA
                          250A]
 CHEMICAL/PHYSICAL DATA   MOLECULAR FORMULA: C8H14O2S2 [USAN 1996]
 CHEMICAL/PHYSICAL DATA   MOLECULAR WEIGHT: 206.33 [USAN 1996]
 CHEMICAL/PHYSICAL DATA   ELEMENTAL COMP: C46.57%, H6.84%, O15.51%,
                          S31.08% [Merck Index 1989]
 SUBSTANCE DELIVERY DATA  DOSAGE FORM: 200 mg tablets. [FDA 250A]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Oral. [FDA 250A]
 MANUFACTURERS            ASTA Medica AG
 REFERENCES               Teichert J, Preiss R. Determination of lipoic
                          acid in human plasma by high-performance
                          liquid chromatography with electrochemical
                          detection. J Chromatogr B Biomed Appl 1995
                          Oct 20;672(2):277-81.
 REFERENCES               Packer L, Witt EH, Tritschler HJ.
                          alpha-Lipoic acid as a biological
                          antioxidant. Free Radic Biol Med. 1995
                          Aug;19(2):227-50.
 REFERENCES               Suzuki YJ, Mizuno M, Tritschler HJ, Packer L.
                          Redox regulation of NF-kappa B DNA binding
                          activity by dihydrolipoate. Biochem Mol Biol
                          Int. 1995 Jun;36(2):241-6.
 REFERENCES               Han D, Tritschler HJ, Packer L. Alpha-lipoic
                          acid increases intracellular glutathione in a
                          human T-lymphocyte Jurkat cell line. Biochem
                          Biophys Res Commun. 1995 Feb 6;207(1):258-64.
 REFERENCES               Shoji S, Furuishi K, Misumi S, Miyazaki T,
                          Kino M, Yamataka K. Thiamine disulfide as a
                          potent inhibitor of human immunodeficiency
                          virus (type-1) production. Biochem Biophys
                          Res Commun. 1994 Nov 30;205(1):967-75.
 REFERENCES               Suzuki YJ, Packer L. Inhibition of NF-kappa B
                          DNA binding by alpha-lipoic acid. Int Conf
                          AIDS. 1994 Aug 7-12;10(2):27 (abstract no.
                          401A).
 REFERENCES               Shoji S, Furuishi K, Misumi S, Miyazaki T,
                          Kino M, Yamataka K, Matsuoka H, Tachibana K.
                          Anti-HIV effects of redox reagents of HIV-1
                          infected cell lines. Int Conf AIDS. 1994 Aug
                          7-12;10(2):114 (abstract no. PA0336).
 REFERENCES               Fuchs J, Schofer H, Milbradt R, Freisleben
                          HJ, Buhl R, Siems W, Grune T. Studies on
                          lipoate effects on blood redox state in human
                          immunodeficiency virus infected patients.
                          Arzneimittelforschung 1993
                          Dec;43(12):1359-62.
 ENTRY MONTH              9511
 LAST REVISION DATE       960502
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
