      Document 0007
 DOCN  DRG0007
 UNIQUE IDENTIFIER        DRG-0240
 NAME OF SUBSTANCE        Heptavalent pneumococcal conjugate vaccine (
                          7-valent ) [NIAID ACTG 292]
 PROTOCOL ID NUMBERS      NIAID ACTG 292
 SECONDARY SOURCE ID      DRG
 DISEASES STUDIED/TREATED HIV-associated pneumococcal disease [NIAID
                          ACTG 292]
 CLASSIFICATION CODE      Vaccine [NIAID ACTG 292]
 CHEMICAL/PHYSICAL DATA   DRUG DESCRIPTION: Pneumococcal capsular
                          saccharides from serotypes 4, 6B, 9V, 14,
                          18C, 19F, and 23F bound to a diphtheria toxin
                          mutant (CRM197) carrier protein. [NIAID ACTG
                          292]
 SUBSTANCE DELIVERY DATA  MODE OF DELIVERY: Intramuscular. [NIAID ACTG
                          292]
 SUBSTANCE DELIVERY DATA  STORAGE INSTRUCTIONS: Store at 2-8 C (35-46
                          F). Do not freeze. [NIAID ACTG 292]
 MANUFACTURERS            Lederle - Praxis Biologicals
 REFERENCES               Sniadack DH, Schwartz B, Lipman H, Bogaerts
                          J, Butler JC, Dagan R, Echaniz-Aviles G,
                          Lloyd-Evans N, Fenoll A, Girgis NI, et al.
                          Potential interventions for the prevention of
                          childhood pneumonia: geographic and temporal
                          differences in serotype and serogroup
                          distribution of sterile site pneumococcal
                          isolates from children--implications for
                          vaccine strategies. Pediatr Infect Dis J 1995
                          Jun;14(6):503-10.
 REFERENCES               Davidson M, Parkinson AJ, Bulkow LR,
                          Fitzgerald MA, Peters HV, Parks DJ. The
                          epidemiology of invasive pneumococcal disease
                          in Alaska, 1986-1990--ethnic differences and
                          opportunities for prevention [see comments].
                          J Infect Dis 1994 Aug;170(2):368-76.
 REFERENCES               Hatano K, Boisot S, DesJardins D, Wright DC,
                          Brisker J, Pier GB. Immunogenic and antigenic
                          properties of a heptavalent
                          high-molecular-weight O-polysaccharide
                          vaccine derived from Pseudomonas aeruginosa.
                          Infect Immun 1994 Sep;62(9):3608-16.
 ENTRY MONTH              9601
 LAST REVISION DATE       960503
 

SOURCE: National Library of Medicine, Bethesda, MD.  Distributed by AEGIS.
