       Document 0935
 DOCN  M9440935
 TI    Neurobiology of simian and feline immunodeficiency virus infections.
 DT    9404
 AU    Lackner AA; Dandekar S; Gardner MB; California Regional Primate Research
       Center, University of; California, Davis 95617-8542.
 SO    Brain Pathol. 1991 Apr;1(3):201-12. Unique Identifier : AIDSLINE
       MED/94122952
 AB    Experimental and clinical evidence indicates that all lentiviruses of
       animals and humans are neurotropic and potentially neurovirulent. The
       prototypic animal lentiviruses, visna virus in sheep and caprine
       arthritis encephalitis virus in goats have been known for decades to
       induce neurologic disease. More recently, infection of the brain with
       the human immunodeficiency virus (HIV) has been linked to an associated
       encephalopathy and cognitive/motor complex. While the visna virus and
       caprine arthritis encephalitis virus are important models of neurologic
       disease they are not optimal for the study of HIV encephalitis because
       immune deficiency is only a minor component of the disease they induce.
       By contrast, the recently isolated lentiviruses from monkeys and cats,
       the simian and feline immunodeficiency viruses (SIV and FIV
       respectively), are profoundly immunosuppressive as well as neurotropic.
       SIV infection of the central nervous system of macaques now provides the
       best animal model for HIV infection of the human brain due to the close
       evolutionary relationship between monkeys and man, the genetic
       relatedness of their respective lentiviruses, and the similarities in
       the neuropathology. This chapter will compare and contrast the
       neurobiology of SIV and FIV with HIV.
 DE    Animal  AIDS Dementia Complex/MICROBIOLOGY/PATHOLOGY  Cats
       Encephalitis/IMMUNOLOGY/*MICROBIOLOGY/PATHOLOGY/PSYCHOLOGY  Feline
       Acquired Immunodeficiency Syndrome/MICROBIOLOGY/*PATHOLOGY  Giant
       Cells/MICROBIOLOGY/PATHOLOGY  Haplorhini  Human  HIV
       Infections/MICROBIOLOGY/PATHOLOGY  HIV-1/ISOLATION & PURIF
       Immunodeficiency Virus, Feline/ISOLATION & PURIF
       Neurons/MICROBIOLOGY/PATHOLOGY  Simian Acquired Immunodeficiency
       Syndrome/MICROBIOLOGY/*PATHOLOGY  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  SIV/ISOLATION & PURIF  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

