       Document 0905
 DOCN  M9440905
 TI    Pseudo oral hairy leukoplakia in a renal allograft recipient.
 DT    9404
 AU    Euvrard S; Kanitakis J; Pouteil-Noble C; Chardonnet Y; Touraine JL;
       Thivolet J; Department of Dermatology, Hopital Edouard Herriot, Lyon,;
       France.
 SO    J Am Acad Dermatol. 1994 Feb;30(2 Pt 2):300-3. Unique Identifier :
       AIDSLINE MED/94124716
 AB    Oral hairy leukoplakia (OHL) is a disorder of the tongue associated with
       Epstein-Barr virus (EBV). OHL is seen mainly in HIV infection but is
       also rarely seen in the course of iatrogenic immunosuppression,
       especially in kidney transplantation; OHL is even more rarely seen in
       immunocompetent hosts. Lesions that clinically and histologically
       mimicked OHL but were not associated with EBV were recently
       characterized as pseudo hairy leukoplakia. We present such a case that
       occurred in a renal allograft recipient; light and electron microscopy,
       immunohistochemistry, and in situ hybridization were used to examine the
       patient for the presence of EBV and human papillomavirus. Two
       independent treatments with topical retinoid and oral amoxicillin
       resulted in complete remission. Pseudo hairy leukoplakia may correspond,
       at least in some cases, to the conditions known as leukoedema and white
       sponge nevus; the distinction of these diseases from OHL is of
       importance because OHL is a hallmark of severe immunosuppression.
 DE    Case Report  Cytoplasm/ULTRASTRUCTURE  Diagnosis, Differential  Female
       Hamartoma/PATHOLOGY  Human  Keratinocytes/PATHOLOGY  *Kidney
       Transplantation  Leukoedema, Oral/PATHOLOGY  Leukoplakia,
       Hairy/*PATHOLOGY  Middle Age  Tongue Diseases/*PATHOLOGY
       Transplantation, Homologous  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

