       Document 0829
 DOCN  M9440829
 TI    HIV-associated psychosis: a study of 20 cases. San Diego HIV
       Neurobehavioral Research Center Group.
 DT    9404
 AU    Sewell DD; Jeste DV; Atkinson JH; Heaton RK; Hesselink JR; Wiley C; Thal
       L; Chandler JL; Grant I; Department of Psychiatry, School of Medicine,
       University of; California, San Diego.
 SO    Am J Psychiatry. 1994 Feb;151(2):237-42. Unique Identifier : AIDSLINE
       MED/94127579
 AB    OBJECTIVE: Psychosis is an uncommon but serious complication of
       infection with HIV. This article presents the results of a study of
       HIV-infected individuals with psychosis. METHOD: The authors evaluated
       20 HIV-infected men who had noniatrogenic new-onset psychosis without
       delirium, current substance abuse, or previous psychotic episodes.
       Clinical, neuropsychological, CSF, magnetic resonance imaging, and
       neuropathologic assessments were made. A comparison group consisting of
       20 nonpsychotic HIV-infected men matched to the psychotic subjects with
       respect to age, race, years of education, and Centers for Disease
       Control HIV stage was also evaluated. RESULTS: The psychotic patients
       differed from the nonpsychotic comparison subjects in having
       significantly higher rates of past stimulant and sedative/hypnotic abuse
       or dependence and, at follow-up, a significantly higher rate of
       mortality. They also showed a trend toward greater global
       neuropsychological impairment. CONCLUSIONS: New-onset psychosis may be,
       at least in part, a manifestation of an HIV-associated encephalopathy.
 DE    Adolescence  Adult  AIDS Dementia Complex/DIAGNOSIS/EPIDEMIOLOGY
       Comorbidity  Diagnosis, Differential  Human  HIV
       Infections/*DIAGNOSIS/EPIDEMIOLOGY  Magnetic Resonance Imaging  Male
       Middle Age  Neuropsychological Tests  Organic Mental Disorders,
       Psychotic/DIAGNOSIS/EPIDEMIOLOGY  Prevalence  Psychotic
       Disorders/*DIAGNOSIS/EPIDEMIOLOGY  Substance Abuse/EPIDEMIOLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

