       Document 0697
 DOCN  M9440697
 TI    Evaluation of autoantibodies to brain proteins in patients with AIDS
       dementia complex.
 DT    9404
 AU    Trujillo JR; Navia B; McLane MF; Worth JL; Lee TH; Essex M; Department
       of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115.
 SO    J Acquir Immune Defic Syndr. 1994 Feb;7(2):103-8. Unique Identifier :
       AIDSLINE MED/94133077
 AB    A high frequency of autoantibodies to brain proteins has been reported
       in HIV-1-positive patients. However, the specificity of this response
       has not been characterized. Using homogenized tissue from three normal
       brains, the presence of autoantibodies to human brain proteins was
       analyzed in 16 HIV-1-positive patients with AIDS dementia complex (ADC),
       10 HIV-1-positive patients without ADC, 10 patients with multiple
       sclerosis, 10 patients with juvenile rheumatoid arthritis, and 10 normal
       controls. Although antibodies to various brain proteins were detected in
       sera from one-third HIV-1-infected individuals with or without ADC, the
       proteins recognized were different among different brains. Only one ADC
       patient had consistent seroreactivity to a 50-kDa brain-specific
       protein. Our results indicate that autoantibodies to brain proteins are
       infrequently present in patients with ADC.
 DE    Absorption  Antibody Specificity  Arthritis, Juvenile
       Rheumatoid/IMMUNOLOGY  Autoantibodies/*ANALYSIS/BLOOD/IMMUNOLOGY  AIDS
       Dementia Complex/*IMMUNOLOGY  Binding, Competitive  Blotting, Western
       Brain/*IMMUNOLOGY  Cell Line  Human  HIV Envelope Protein
       gp120/IMMUNOLOGY  HIV Infections/IMMUNOLOGY  *HIV-1  Multiple
       Sclerosis/IMMUNOLOGY  Proteins/IMMUNOLOGY  Recombinant
       Proteins/IMMUNOLOGY  Support, U.S. Gov't, Non-P.H.S.  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

