       Document 0663
 DOCN  M9440663
 TI    Maternal IgG1 and IgA antibody to V3 loop consensus sequence and
       maternal-infant HIV-1 transmission.
 DT    9404
 AU    Markham RB; Coberly J; Ruff AJ; Hoover D; Gomez J; Holt E; Desormeaux J;
       Boulos R; Quinn TC; Halsey NA; Department of Immunology and Infectious
       Diseases, Johns Hopkins; University School of Hygiene and Public Health,
       Baltimore, MD; 21205.
 SO    Lancet. 1994 Feb 12;343(8894):390-1. Unique Identifier : AIDSLINE
       MED/94133801
 AB    Maternal-infant transmission of HIV-1 occurs in 13-40% of pregnancies.
       Studies on transmission of maternal immunity to HIV antigens have used
       antigens from viruses not representative of clinical isolates and have
       been conflicting. Using a consensus peptide sequence based on HIV
       isolates found in Haiti, we found that Haitian mothers who transmitted
       infection to their offspring had significantly higher mean
       concentrations of IgG1 antibodies to the V3 loop of the primary
       neutralising domain of the viral envelope (gp 160) than non-transmitters
       (p = 0.02). Concentrations of IgA antibody to this domain were similar
       in transmitters and non-transmitters.
 DE    Amino Acid Sequence  Female  Gene Products, env/*IMMUNOLOGY  Human  HIV
       Infections/*IMMUNOLOGY/TRANSMISSION  HIV-1/*IMMUNOLOGY  IgA/BLOOD
       IgG/*BLOOD  Immunity, Maternally-Acquired  Infant  Molecular Sequence
       Data  Pregnancy  Pregnancy Complications, Infectious/*IMMUNOLOGY
       Protein Precursors/*IMMUNOLOGY  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

