       Document 0555
 DOCN  M9440555
 TI    Perinatal findings in children born to HIV-infected mothers. The
       European Collaborative Study.
 DT    9404
 SO    Br J Obstet Gynaecol. 1994 Feb;101(2):136-41. Unique Identifier :
       AIDSLINE MED/94137666
 AB    OBJECTIVE: To explore in children born to HIV-infected women, the
       association between a child's HIV infection status and birthweight,
       gestational age, congenital abnormalities and other perinatal findings.
       DESIGN: A prospective study of children born to women known to be
       HIV-infected at or before the time of delivery enrolled in the European
       Collaborative Study. SETTING: Nineteen European centres. SUBJECTS: A
       cohort of 853 children with known HIV infection status. RESULTS: There
       was no evidence for an HIV dysmorphic syndrome, and the frequency of
       congenital abnormalities was similar in infected and uninfected children
       with no consistent pattern of defects. Injecting drug use during
       pregnancy had the most marked effect on birthweight and gestational age.
       Multivariate analysis demonstrated a weak association between
       birthweight and the child's HIV infection status, but this could partly
       be explained by the confounding effect of maternal immunological HIV
       status. HIV infection in the infant was not associated with gestational
       age, and the mean and distribution of gestational age were similar for
       infected and noninfected children. CONCLUSIONS: The finding that
       HIV-infected and noninfected children are of similar birthweight, the
       absence of a dysmorphic syndrome and no evidence of associated
       congenital abnormalities suggest that a substantial proportion of
       infection occurs late in pregnancy or at the time of delivery.
 DE    *Birth Weight  Cohort Studies  CD4-CD8 Ratio  Europe/EPIDEMIOLOGY
       Female  Gestational Age  Human  *HIV Infections/IMMUNOLOGY  Infant,
       Newborn  Infant, Newborn, Diseases/EPIDEMIOLOGY  Pregnancy  *Pregnancy
       Complications, Infectious/IMMUNOLOGY  Prospective Studies  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

