       Document 0365
 DOCN  M9440365
 TI    Gastrointestinal manifestations of AIDS in children.
 DT    9404
 AU    Haller JO; Cohen HL; Department of Radiology, State University of New
       York Health; Science Center, Downstate Medical Center, Brooklyn 11203.
 SO    AJR Am J Roentgenol. 1994 Feb;162(2):387-93. Unique Identifier :
       AIDSLINE MED/94144485
 AB    The gastrointestinal manifestations of AIDS in children are related to
       opportunistic infections, lymphoproliferative disease, and cancer. The
       infections that affect the gastrointestinal tract at different sites
       also occur in patients without AIDS. However, in children with AIDS, the
       infections are more severe, often relapse, and are harder to eradicate.
       Candidiasis is the most common infection in the esophagus, but
       infections caused by herpes simplex virus and cytomegalovirus also are
       common. Radiologic findings include ulcerations, a cobblestone
       appearance, and disordered motility. Gastritis and enteritis are usually
       caused by cytomegalovirus. Lesions produced by this virus include
       ulcerations caused by ischemic necrosis as a result of vasculitis.
       Barium studies show increased nodularity and effacement of mucosa. Other
       organisms (typically found in all immunocompromised patients) include
       Mycobacterium avium-intracellulare, Mycobacterium tuberculosis,
       Campylobacter, Giardia, and Cryptosporidium. Colitis and proctitis are
       caused by many of the same enteric pathogens. Cytomegalovirus is the
       most virulent, causing necrosis, perforation, and often death. Lymphoma,
       smooth muscle tumors, and Kaposi's sarcoma are the most common neoplasms
       encountered in children with AIDS.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adolescence
       AIDS-Related Opportunistic Infections/*RADIOGRAPHY  Child  Child,
       Preschool  Esophageal Diseases/*COMPLICATIONS/RADIOGRAPHY
       Gastrointestinal Diseases/*COMPLICATIONS/RADIOGRAPHY  Gastrointestinal
       Neoplasms/COMPLICATIONS/*RADIOGRAPHY  Human  Infant  Lymphoma,
       AIDS-Related/*RADIOGRAPHY  Sarcoma, Kaposi's/ETIOLOGY/*RADIOGRAPHY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

