       Document 0327
 DOCN  M9440327
 TI    Coccidioidomycosis.
 DT    9404
 AU    Pappagianis D; Department of Medical Microbiology and Immunology, School
       of; Medicine, University of California, Davis 95616.
 SO    Semin Dermatol. 1993 Dec;12(4):301-9. Unique Identifier : AIDSLINE
       MED/94145863
 AB    Coccidioidomycosis is usually acquired by inhalation of Coccidioides
       immitis in certain areas of the Western Hemisphere. However, the disease
       may occur far away in individuals who have visited or lived in, then
       departed from, the endemic areas. The disease which can affect normal
       and immunocompromised individuals, has many manifestations resembling
       those of many diseases. The diagnosis is usually not difficult and can
       be accomplished by histopathological, cultural, and serological methods.
       Therapy can be surgical and/or medical. The latter can make use of
       parenteral amphotericin B and its lipid-complex, or the azoles
       ketoconazole, fluconazole, and itraconazole. However coccidioidal
       meningitis, coccidioidal arthritis, and acute coccidioidal respiratory
       insufficiency pose significant challenges to the available therapy.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Amphotericin
       B/THERAPEUTIC USE  Antifungal Agents/THERAPEUTIC USE
       *Coccidioidomycosis/COMPLICATIONS/DIAGNOSIS/MICROBIOLOGY/THERAPY
       *Dermatomycoses/COMPLICATIONS/DIAGNOSIS/MICROBIOLOGY/THERAPY  Drug
       Interactions  Drug Therapy, Combination  Human  Surgery,
       Operative/METHODS  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

