       Document 0229
 DOCN  M9440229
 TI    Quantitative anti-p24 determinations can predict the risk of vertical
       transmission. Swiss HIV and Pregnancy Collaborative Study Group.
 DT    9404
 AU    Erb P; Krauchi S; Burgin D; Biedermann K; Camli C; Rudin C; Institute
       for Medical Microbiology, University of Basel,; Switzerland.
 SO    J Acquir Immune Defic Syndr. 1994 Mar;7(3):261-4. Unique Identifier :
       AIDSLINE MED/94149560
 AB    Quantitative serum antibody to p24 was evaluated as a predictor of risk
       of vertical transmission of human immunodeficiency virus type 1 (HIV-1)
       infection. HIV-positive mothers, 13 with HIV-infected children and 24
       with noninfected children were investigated during pregnancy and at the
       time of delivery. A statistically significant difference in anti-p24
       titers was found between the mothers with infected and those with
       noninfected children independent of whether antibodies were measured
       during pregnancy or at the time of delivery. High anti-p24 levels
       correlated with a low risk of vertical transmission, whereas low
       anti-p24 titers were associated with an increased risk of vertical
       transmission. Although the number of CD4+ T-cells was lower and
       neopterin and beta-2 microglobulin values were higher in the group of
       mothers with infected children than in the noninfected group, no
       statistical significance was achieved due to the small sample size.
 DE    beta 2-Microglobulin/ANALYSIS  Biopterin/ANALOGS & DERIVATIVES/BLOOD
       Female  Human  HIV Envelope Protein gp41/*BLOOD  HIV
       Infections/*TRANSMISSION  *HIV-1  Infant, Newborn  Leukocyte Count
       Pregnancy  *Pregnancy Complications, Infectious  Prognosis  Risk Factors
       Support, Non-U.S. Gov't  T4 Lymphocytes  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

