       Document 0215
 DOCN  M9440215
 TI    Alterations of the p53 gene in Epstein-Barr virus-associated
       immunodeficiency-related lymphomas.
 DT    9404
 AU    Edwards RH; Raab-Traub N; Department of Microbiology and Immunology,
       University of North; Carolina, Chapel Hill 27599-7295.
 SO    J Virol. 1994 Mar;68(3):1309-15. Unique Identifier : AIDSLINE
       MED/94149817
 AB    Mutations of the p53 tumor suppressor gene are among the most common
       genetic alterations found in many different human malignancies,
       including those of the colon, lung, and breast. Alterations in wild-type
       p53 lead to loss of the suppressor function and thus contribute to
       tumorigenesis. The potential role of p53 mutations in a sampling of
       B-cell lymphomas, the majority of which were associated with
       Epstein-Barr virus (EBV), was investigated. Twenty-six biopsy specimens
       from immunocompromised patients, including allograft recipients and
       patients with AIDS, Wiscott-Aldrich syndrome, and human T-cell leukemia
       virus type 1 infection, in comparison with three Burkitt lymphomas and
       four Burkitt lymphoma cell lines were analyzed. Mutation in p53 was
       detected in all four Burkitt lymphoma cell lines as well as the three
       Burkitt lymphoma biopsy specimens. In patients with AIDS, 5 of 10
       lymphomas were EBV positive, and 1 had a mutation in p53. Mutation in
       p53 was not detected in 14 EBV-positive lymphomas which arose in
       transplant recipients. These data indicate that with the exception of
       Burkitt lymphomas, p53 mutations are not involved in the majority
       EBV-positive B-cell lymphomas which develop in immunocompromised
       patients.
 DE    Alleles  Base Sequence  Biopsy  Burkitt's Lymphoma/*GENETICS  Genes,
       p53/*GENETICS  *Herpesvirus 4, Human  Human  Immunocompromised Host
       Lymphoma, B-Cell/*GENETICS/MICROBIOLOGY  Molecular Sequence Data
       Mutation  Polymerase Chain Reaction  Polymorphism (Genetics)/GENETICS
       Sequence Analysis, DNA  Sequence Deletion  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

