       Document 0212
 DOCN  M9440212
 TI    Inhibition of murine AIDS (MAIDS), development by the transplantation of
       bone marrow cells carrying the Fv-4 resistance gene to MAIDS
       virus-infected mice.
 DT    9404
 AU    Nakagawa Y; Kakimi K; Ling W; Kubo Y; Higo K; Masuda T; Kuribayashi K;
       Iwashiro M; Komatz Y; Hirama T; et al; Institute of Virus Research,
       Kyoto University, Japan.
 SO    J Virol. 1994 Mar;68(3):1438-41. Unique Identifier : AIDSLINE
       MED/94149831
 AB    To examine whether the resistance allele of the Fv-4 gene (the Fv-4r
       gene) is a dominant inhibitory-product-encoding gene which an be used to
       prevent the development of murine AIDS (MAIDS), bone marrow cells from
       BALB/c-Fv-4wr mice were transplanted into BALB/c mice and C57BL/6 mice
       infected with MAIDS virus. Almost all of the virus-infected BALB/c and
       C57BL/6 mice developed MAIDS within 4 months and died 2 or 3 months
       later. However, when the virus-infected mice were subjected to cobalt
       irradiation and then given an intravenous injection of 10(7)
       BALB/c-Fv-4wr mouse bone marrow cells, the recipient mice survived much
       longer than the untreated mice, which suggests that the Fv-4 gene is a
       dominant inhibitory gene that is potentially useful in gene therapy of
       MAIDS.
 DE    Animal  Animals, Newborn  *Bone Marrow Transplantation  Flow Cytometry
       Gene Therapy/*METHODS  Genes, Dominant/*GENETICS  H-2 Antigens/ANALYSIS
       Immunity, Natural/*GENETICS  Mice  Mice, Inbred BALB C  Mice, Inbred
       C57BL  Murine Acquired Immunodeficiency Syndrome/MORTALITY/*THERAPY
       Spleen/IMMUNOLOGY  Support, Non-U.S. Gov't  Survival Analysis  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

