       Document 0206
 DOCN  M9440206
 TI    Genomic cloning and complete sequence analysis of a highly divergent
       African human immunodeficiency virus isolate.
 DT    9404
 AU    Vanden Haesevelde M; Decourt JL; De Leys RJ; Vanderborght B; van der
       Groen G; van Heuverswijn H; Saman E; Innogenetics N.V., Gent, Belgium.
 SO    J Virol. 1994 Mar;68(3):1586-96. Unique Identifier : AIDSLINE
       GENBANK/L23119
 AB    Analysis of the complete sequence of a human immunodeficiency virus
       (HIV) isolate (Ant70) obtained from a Cameroonian patient indicates that
       this virus is the most divergent strain within the HIV-1 family hitherto
       described. Comparison of the Pol protein, usually highly conserved
       within the HIV-1 family, shows only about 73% similarity with the HIVmm
       isolate, whereas for the more variable proteins such as envelope,
       similarities of 50% or lower are found. The principal neutralizing
       determinant (V3 loop) and the immunodominant region within gp41 also
       contain some unusual substitutions, which may have implications for
       protein function as well as for serological assays based on these
       regions. Phylogenetic analyses show that this isolate occupies a unique
       position relative to the human HIV-1 isolates and the recently described
       SIVcpz virus, indicating that this Cameroonian isolate may provide us
       with new insights into the origins of the HIV-1 family.
 DE    Amino Acid Sequence  Base Sequence  Cameroon/EPIDEMIOLOGY  Cloning,
       Molecular  Comparative Study  Female  Genes, env/GENETICS  Genes,
       Viral/GENETICS  *Genome, Viral  Human  HIV
       Infections/EPIDEMIOLOGY/MICROBIOLOGY  HIV-1/*CLASSIFICATION/GENETICS
       Male  Molecular Sequence Data  Phylogeny  Prevalence  Sequence Analysis,
       DNA  Sequence Homology, Amino Acid  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

