       Document 0190
 DOCN  M9440190
 TI    Redesignation of the RNase D activity associated with retroviral reverse
       transcriptase as RNase H.
 DT    9404
 AU    Hostomsky Z; Hughes SH; Goff SP; Le Grice SF; Agouron Pharmaceuticals
       Inc., San Diego, California 92121.
 SO    J Virol. 1994 Mar;68(3):1970-1. Unique Identifier : AIDSLINE
       MED/94149893
 AB    In the presence of Mn2+, reverse transcriptase of both human
       immunodeficiency virus and murine leukemia virus hydrolyzes duplex RNA.
       However, designating this novel activity RNase D conflicts with
       Escherichia coli RNase D, which participates in tRNA processing. On the
       basis of its location in the RNase H domain, we propose that this novel
       retroviral activity be redesignated RNase H*.
 DE    Endoribonucleases/CLASSIFICATION  Retroviridae/*ENZYMOLOGY  Reverse
       Transcriptase/*METABOLISM  Ribonuclease H, Calf Thymus/CLASSIFICATION
       Ribonucleases/*CLASSIFICATION  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

