       Document 0093
 DOCN  M9440093
 TI    Long-latency event-related potentials in asymptomatic human
       immunodeficiency virus type 1 infection.
 DT    9404
 AU    Connolly S; Manji H; McAllister RH; Fell M; Loveday C; Kirkis C; Herns
       M; Sweeney B; Sartawi O; Durrance P; et al; Department of Clinical
       Neurophysiology, University College London; Medical School, Middlesex
       Hospital, England.
 SO    Ann Neurol. 1994 Feb;35(2):189-96. Unique Identifier : AIDSLINE
       MED/94153003
 AB    As part of the Medical Research Council prospective study of the
       neurological and neuropsychological complications of human
       immunodeficiency virus (HIV) infection, long-latency event-related
       potentials were recorded in a cohort of homosexual and bisexual men. The
       latencies and amplitudes of the potentials, recorded from three scalp
       sites, were compared with the scores from neuropsychological tests of
       memory, attention, and concentration and with markers of immune
       function. The findings from 94 men were analyzed in the cross-sectional
       study of whom 47 were HIV seropositive without symptoms or signs of HIV
       type 1 (HIV-1) infection, 24 had progressed to the symptomatic stages of
       the disease, and 23 were persistently HIV seronegative. There were no
       consistently significant differences between the three subject groups in
       mean latencies and amplitudes of the P300 and N200 or in the numbers of
       abnormal P300 latencies. There were no significant correlations between
       either the neuropsychological tests scores or the immune measures (CD4
       lymphocyte count and beta 2 microglobulin level) and the
       neurophysiological parameters. On repeated testing an average of 2 years
       later, there was no evidence of a significant trend towards
       deterioration in 30 HIV-seropositive subjects who remained asymptomatic
       compared with 22 HIV seronegatives. These findings indicate that there
       is no neurophysiological evidence of cognitive dysfunction in the
       asymptomatic stages of HIV-1 infection.
 DE    beta 2-Microglobulin/METABOLISM  Adult  Brain/*PHYSIOPATHOLOGY  *Evoked
       Potentials  Human  HIV
       Infections/IMMUNOLOGY/METABOLISM/*PHYSIOPATHOLOGY/PSYCHOLOGY  *HIV-1
       Leukocyte Count  Male  Middle Age  Neuropsychological Tests  Reaction
       Time  Support, Non-U.S. Gov't  T4 Lymphocytes  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

