       Document 0954
 DOCN  M9540954
 TI    Bronchoalveolar lavage immunoglobulin A and G and antiproteases
       correlate with changes in diffusion indices during the natural course of
       pulmonary sarcoidosis.
 DT    9504
 AU    Vandenplas O; Depelchin S; Delaunois L; Delwiche JP; Sibille Y;
       Pulmonary Section, University Hospital of Mont-Godinne, Yvoir,; Belgium.
 SO    Eur Respir J. 1994 Oct;7(10):1856-64. Unique Identifier : AIDSLINE
       MED/95129669
 AB    We wanted to determine whether cell populations and soluble components
       in bronchoalveolar lavage (BAL) could be useful in predicting the
       outcome of lung function and chest radiography in patients with
       untreated pulmonary sarcoidosis. Analysis of soluble proteins in BAL
       fluid, included the levels of immunoglobulins and the two major
       antiproteases, alpha 2-macroglobulin (alpha 2-M) and alpha 1-protease
       inhibitor (alpha 1-PI), expressed as a relative coefficient of excretion
       (RCE). Thirty one nonsmoking patients with biopsy proven sarcoidosis,
       who remained untreated, had reassessment of lung function tests after
       6-54 months (median 21 months). No correlation was observed between
       initial BAL data and changes in lung volumes and radiographic opacities.
       By contrast, the initial BAL immunoglobulin A and G (IgA and IgG) RCE
       correlated inversely with the change in transfer factor for carbon
       monoxide (TLCO) in the whole group and in patients with sarcoidosis of
       recent origin (estimated disease duration < 6 months). In the whole
       group and in patients with longstanding disease (estimated disease
       duration > 24 months, or radiographic Stage 4), the change in carbon
       monoxide transfer coefficient (KCO) correlated negatively with the
       initial alpha 1-PI RCE and positively with the initial helper to
       suppressor T-cell (T4/T8) ratio. By contrast, no significant difference
       in BAL cellular and protein data was found between patients with recent
       and longstanding sarcoidosis.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    alpha Macroglobulins/*ANALYSIS  alpha 1-Antitrypsin/*ANALYSIS  Adult
       Aged  Bronchoalveolar Lavage Fluid/*CHEMISTRY  CD4-CD8 Ratio  Female
       Human  IgA/*ANALYSIS  IgG/*ANALYSIS  Lung/RADIOGRAPHY  Male  Middle Age
       Pulmonary Diffusing Capacity  Respiratory Mechanics  Sarcoidosis,
       Pulmonary/IMMUNOLOGY/*PHYSIOPATHOLOGY/RADIOGRAPHY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

