                    
                              UPDATE (part 1)
                              ~~~~~~~~~~~~~~~
         The main changes since publication of the manual for PEPI 
         Version 2.0 are listed below, and described in more detail in 
         part 2 (UPDATE2.TXT).  
         
         Latest program version numbers are listed in FILELIST.TXT; 
         programs numbered 2.0 have not been changed. 
         
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         The manual's Program Finder can now be installed in Windows.
         
         The DerSimonian-Laird procedure has been added.  This computes 
         an overall measure of association based on the findings in 
         separate studies or strata, using a random-effects model, and 
         may be helpful in meta-analyses based on studies with 
         heterogeneous results.  The procedure is provided as an option 
         in CASECONT (for odds ratios), RATES1 and RATES2 (for risk and 
         rate ratios), and COMBINE (for other measures). 
         
         CASECONT can now compute the exact power of exact Fisher and 
         mid-P tests. 
         
         MATCHED and PAIRS now provide exact probabilities and confidence 
         intervals for odds ratios, and CONFINT provides approximate mid-
         P confidence intervals for proportions and rates when it does 
         not compute exact intervals. 
         
         COMBINE can now accept either confidence intervals or standard 
         errors of the measures to be combined; it can now compute and 
         combine effect sizes (standardized differences between means). 
         
         SCRN now displays ROC curves showing the association between a 
         test's sensitivity and its false positive rate, with their 95% 
         confidence bounds. 

         KAPPA now provides adjusted kappa values (for two ratings using a 
         dichotomous scale) that compensate for the effects of bias and 
         unequal prevalences of the categories.

         DIFFER can now estimate the effect of regression to the mean.
         
         WHATS can now compute permutations and combinations.  The 
         factorial function has been extended, and now accepts numbers up 
         to 1,754. 

         SEASONAL now provides Hewitt's rank-sum test.

         EXACT2XK is now faster, and CASECONT and RATES2 are much faster 
         when computing exact probabilities and exact confidence 
         intervals for odds ratios and person-time rate ratios for 
         stratified data. 
         
         The accuracy of the function for estimating F from a P value has 
         been enhanced.  The modified function is used in CONFINT, PVALUE 
         and PAIRS.  
         
         An error in MANNWHIT (in the handling of zero and negative 
         values entered in the Wilcoxon test) has been corrected. 

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