     * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *  
     *                              R T E C S                              *  
     *                                                                     *  
     * Produced by : National Institute for Occupational Safety and Health *  
     * Provided by : Canadian Centre for Occupational Health and Safety    *  
     * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *  
  
                         *** SUBSTANCE IDENTIFICATION ***                      
  
 RTECS NUMBER               : WH8575000
 DATE OF LAST UPDATE        : 9009
 NUMBER OF DATA ITEMS CITED : 24
 CHEMICAL NAME :
    STANNANE, HYDROXYTRIPHENYL-
 CAS REGISTRY NUMBER        : 76-87-9
 MOLECULAR FORMULA          : C18-H16-O-Sn
 MOLECULAR WEIGHT           : 367.03
 WISWESSER LINE NOTATION    : Q-SN-R&R&R
 SUBSTANCE INVESTIGATED AS  : Agricultural Chemical
                              Tumorigen
                              Organometallic
                              Mutagen
                              Reproductive Effector
                              Primary Irritant
 SYNONYM(S)/TRADE NAME(S)   :
    : DOWCO 186
    : DU-TER
    : DU-TER W-50
    : DUTER
    : ENT 28009
    : FENOLOVO
    : FINTINE HYDROXYDE
    : FINTIN HYDROXID
    : FENTIN HYDROXIDE
    : FINTIN HYDROXYDE
    : FINTIN IDROSSIDO
    : FLO-TIN 4L
    : HAITIN
    : HYDROXYDE DE TRIPHENYL-ETAIN
    : HYDROXYTRIPHENYLSTANNANE
    : HYDROXYTRIPHENYLTIN
    : IDROSSIDO DI STAGNO TRIFENILE
    : NCI-C00260
    : OMS 1017
    : PHENOSTAT-H
    : SUZU H
    : TIN, HYDROXYTRIPHENYL-
    : TPTH
    : TPTOH
    : TRIFENYLSTANNIUMHYDROXID
    : TRIFENYL-TINHYDROXYDE
    : TRIPHENYLSTANNIUM HYDROXIDE
    : TRIPHENYLTIN HYDROXIDE
    : TRIPHENYLTIN OXIDE
    : TRIPHENYL-ZINNHYDROXID
    : TUBOTIN
    : VANCIDE KS
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Irritation
 ROUTE OF ADMINISTRATION    : Eye(s)
 ORGANISM OBSERVED          : Rodent - rabbit
 CHEMICAL AMT/CONC/DUR      : 10 mg
 TEST OR DOSAGE TYPE        : Standard Draize test
 CITED REFERENCE            : Clinical Toxicology.  Volume(issue)/page/year:
                              13,281,78
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Irritation
 ROUTE OF ADMINISTRATION    : Eye(s)
 ORGANISM OBSERVED          : Rodent - guinea pig
 CHEMICAL AMT/CONC/DUR      : 100%/2S
 TEST OR DOSAGE TYPE        : Rinsed Draize test
 REACTION SEVERITY          : Severe
 CITED REFERENCE            : Toxicology and Applied Pharmacology. 
                              Volume(issue)/page/year: 14,628,69
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Mutation
 TEST OR DOSAGE TYPE        : Oncogenic transformation
 ORGANISM OBSERVED          : Rodent - rat
 TEST CONDUCTED ON          : Embryo
 CHEMICAL AMT/CONC/DUR      : 19 ng/plate
 CITED REFERENCE            : JAT, Journal of Applied Toxicology. 
                              Volume(issue)/page/year: 1,190,81
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Reproductive
 ROUTE OF ADMINISTRATION    : Oral
 ORGANISM OBSERVED          : Rodent - rat
 TEST OR DOSAGE TYPE        : TDL0 - Lowest published toxic dose
 CHEMICAL AMT/CONC/DUR      : 105 mg/kg
 TEST DURATION/PERIOD       : female 8-14 day(s) after conception
 BIOMEDICAL MANIFESTATION   : Reproductive - Embryo or Fetus - fetotoxicity
                              (except death, eg., stunted fetus)
 CITED REFERENCE            : Clinical Toxicology.  Volume(issue)/page/year:
                              13,281,78
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Reproductive
 ROUTE OF ADMINISTRATION    : Oral
 ORGANISM OBSERVED          : Rodent - rat
 TEST OR DOSAGE TYPE        : TDL0 - Lowest published toxic dose
 CHEMICAL AMT/CONC/DUR      : 140 mg/kg
 TEST DURATION/PERIOD       : female 1-7 day(s) after conception
 BIOMEDICAL MANIFESTATION   : Reproductive - Fertility - litter size (# fetuses
                              per litter; measured before birth)
 CITED REFERENCE            : Clinical Toxicology.  Volume(issue)/page/year:
                              13,281,78
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Reproductive
 ROUTE OF ADMINISTRATION    : Oral
 ORGANISM OBSERVED          : Rodent - rat
 TEST OR DOSAGE TYPE        : TDL0 - Lowest published toxic dose
 CHEMICAL AMT/CONC/DUR      : 140 mg/kg
 TEST DURATION/PERIOD       : female 1-7 day(s) after conception
 BIOMEDICAL MANIFESTATION   : Reproductive - Fertility - other measures of
                              fertility
 CITED REFERENCE            : Toxicology Annual.  Volume(issue)/page/year:
                              3,281,79
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Reproductive
 ROUTE OF ADMINISTRATION    : Oral
 ORGANISM OBSERVED          : Rodent - rat
 TEST OR DOSAGE TYPE        : TDL0 - Lowest published toxic dose
 CHEMICAL AMT/CONC/DUR      : 105 mg/kg
 TEST DURATION/PERIOD       : female 8-14 day(s) after conception
 BIOMEDICAL MANIFESTATION   : Reproductive - Fertility - post-implantation
                              mortality (dead and/or resorbed implants per
                              total number of implants)
 CITED REFERENCE            : Toxicology Annual.  Volume(issue)/page/year:
                              3,281,79
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Toxic
 ROUTE OF ADMINISTRATION    : Oral
 ORGANISM OBSERVED          : Rodent - rat
 TEST OR DOSAGE TYPE        : LD50 - Lethal dose 50 percent kill
 CHEMICAL AMT/CONC/DUR      : 46 mg/kg
 BIOMEDICAL MANIFESTATION   : Toxic effects not yet reviewed
 CITED REFERENCE            : Progress Report for Contract No.
                              NIH-NCI-E-C-72-3252, Submitted to the National
                              Cancer Institute by Litton Bionetics, Inc.
                              Volume(issue)/page/year: NCI-E-C-72-3252,73
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Toxic
 ROUTE OF ADMINISTRATION    : Intraperitoneal
 ORGANISM OBSERVED          : Rodent - rat
 TEST OR DOSAGE TYPE        : LDL0 - Lowest published lethal dose
 CHEMICAL AMT/CONC/DUR      : 100 mg/kg
 BIOMEDICAL MANIFESTATION   : Toxic effects not yet reviewed
 CITED REFERENCE            : National Academy of Sciences, National Research
                              Council, Chemical-Biological Coordination Center,
                              Review.  Volume(issue)/page/year: 5,46,53
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Toxic
 ROUTE OF ADMINISTRATION    : Oral
 ORGANISM OBSERVED          : Rodent - mouse
 TEST OR DOSAGE TYPE        : LD50 - Lethal dose 50 percent kill
 CHEMICAL AMT/CONC/DUR      : 209 mg/kg
 BIOMEDICAL MANIFESTATION   : Details of toxic effects not reported other than
                              lethal dose value
 CITED REFERENCE            : Yakkyoku.  Pharmacy.  Volume(issue)/page/year:
                              30,505,79
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Toxic
 ROUTE OF ADMINISTRATION    : Intraperitoneal
 ORGANISM OBSERVED          : Rodent - mouse
 TEST OR DOSAGE TYPE        : LDL0 - Lowest published lethal dose
 CHEMICAL AMT/CONC/DUR      : 8500 ug/kg
 BIOMEDICAL MANIFESTATION   : Toxic effects not yet reviewed
 CITED REFERENCE            : Toxicology and Applied Pharmacology. 
                              Volume(issue)/page/year: 23,288,72
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Toxic
 ROUTE OF ADMINISTRATION    : Skin
 ORGANISM OBSERVED          : Rodent - rabbit
 TEST OR DOSAGE TYPE        : LD50 - Lethal dose 50 percent kill
 CHEMICAL AMT/CONC/DUR      : 1600 mg/kg
 BIOMEDICAL MANIFESTATION   : Details of toxic effects not reported other than
                              lethal dose value
 CITED REFERENCE            : Farm Chemicals Handbook. 
                              Volume(issue)/page/year: -,C300,89
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Toxic
 ROUTE OF ADMINISTRATION    : Oral
 ORGANISM OBSERVED          : Rodent - guinea pig
 TEST OR DOSAGE TYPE        : LD50 - Lethal dose 50 percent kill
 CHEMICAL AMT/CONC/DUR      : 27100 ug/kg
 BIOMEDICAL MANIFESTATION   : Details of toxic effects not reported other than
                              lethal dose value
 CITED REFERENCE            : Pesticide Manual.  Volume(issue)/page/year:
                              8,391,87
  
                            *** HEALTH HAZARD DATA ***                         
  
 INVESTIGATED EFFECT        : Toxic
 ROUTE OF ADMINISTRATION    : Unreported
 ORGANISM OBSERVED          : Mammal - species unspecified
 TEST OR DOSAGE TYPE        : LD50 - Lethal dose 50 percent kill
 CHEMICAL AMT/CONC/DUR      : 500 mg/kg
 BIOMEDICAL MANIFESTATION   : Toxic effects not yet reviewed
 CITED REFERENCE            : "Chemistry of Pesticides," Melnikov, N.N., New
                              York, Springer-Verlag New York, Inc., 1971 
                              Volume(issue)/page/year: -,302,71
  
                       *** REVIEW ***
  
 DESCRIPTION                : ACGIH TLV-TWA 0.1 mg(Sn)/m3;STEL 0.2 mg/m3 (skin)
 CITED REFERENCE            : "Documentation of the Threshold Limit Values and
                              Biological Exposure Indices," 5th ed.,
                              Cincinnati, OH, American Conference of
                              Governmental Industrial Hygienists, Inc., 1986 
                              Volume(issue)/page/year: 5,75(88),86
  
                       *** REVIEW ***
  
 DESCRIPTION                : TOXICOLOGY REVIEW
 CITED REFERENCE            : Environmental Quality and Safety. 
                              Volume(issue)/page/year: 4,80,75
  
                       *** U.S. STANDARDS AND REGULATIONS ***
  
 DESCRIPTION                : EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION
                              OR RE-REGISTRATION
 CITED REFERENCE            : Federal Register.  Volume(issue)/page/year:
                              54,7740,89
  
                       *** U.S. STANDARDS AND REGULATIONS ***
  
 DESCRIPTION                : MSHA STANDARD-air:TWA 0.1 mg(Sn)/m3
 CITED REFERENCE            : "Documentation of Threshold Limit Values for
                              Substances in Workroom Air." For publisher
                              information, see 85INA8. 
                              Volume(issue)/page/year: 3,258,71
  
                       *** U.S. STANDARDS AND REGULATIONS ***
  
 DESCRIPTION                : OSHA PEL:8H TWA 0.1 mg(Sn)/m3
 CITED REFERENCE            : Federal Register.  Volume(issue)/page/year:
                              54,2923,89
  
                       *** U.S. STANDARDS AND REGULATIONS ***
  
 DESCRIPTION                : OSHA PEL FINAL:8H TWA 0.1 mg(Sn)/m3 (skin)
 CITED REFERENCE            : Federal Register.  Volume(issue)/page/year:
                              54,2923,89
  
                       *** NIOSH RECOMMENDED EXPOSURE LIMIT ***
  
 DESCRIPTION                : NIOSH REL TO ORGANOTIN COMPOUND-air:10H TWA 0.1
                              mg(Sn)/m3
 CITED REFERENCE            : MMWR.  Morbidity and Mortality Weekly Report. 
                              Volume(issue)/page/year: 37(S-7),22,88
  
                       *** STATUS IN U.S. ***
  
 DESCRIPTION                : EPA GENETOX PROGRAM 1988, Negative:
                              Carcinogenicity-mouse/rat
  
                       *** STATUS IN U.S. ***
  
 DESCRIPTION                : EPA TSCA CHEMICAL INVENTORY, JUNE 1990
  
                       *** STATUS IN U.S. ***
  
 DESCRIPTION                : NCI CARCINOGENESIS BIOASSAY (FEED);NO
                              EVIDENCE:MOUSE,RAT
 CITED REFERENCE            : National Cancer Institute Carcinogenesis
                              Technical Report Series. Volume(issue)/page/year:
                              NCI-TR-139,78





