       Document 0891
 DOCN  M95A0891
 TI    The natural history and spectrum of idiopathic dilated cardiomyopathy,
       including HIV and peripartum cardiomyopathy.
 DT    9510
 AU    Cetta F; Michels VV; A-1 Echo Laboratory, Mayo Clinic, Rochester, MN
       55905, USA.
 SO    Curr Opin Cardiol. 1995 May;10(3):332-8. Unique Identifier : AIDSLINE
       MED/95337539
 AB    Idiopathic dilated cardiomyopathy (IDCM) is an often fatal heart disease
       characterized by ventricular dilation and reduced systolic function.
       Despite advances in diagnostic and therapeutic techniques that have
       enabled earlier identification of patients with IDCM, the etiology of
       the disease in most patients remains unknown. The current 5-year
       survival rate for patients with asymptomatic IDCM approaches 80%; this
       is a significant improvement compared with earlier reports of the
       natural history of IDCM. Men are more commonly afflicted with IDCM, but
       women with IDCM tend to present with more advanced disease. Recent
       analysis of 3-year transplant-free survival reveals no gender
       differences, however. Survival in children with IDCM is variable; 30% of
       infants die within 2 years of diagnosis, but 5-year survival for
       childhood IDCM is 60% to 84%. An association of IDCM with the peripartum
       period is well recognized. The etiology of peripartum cardiomyopathy
       remains unknown, and some cases are familial. This disease is reversible
       in approximately 50% of patients, and in patients with intractable
       congestive heart failure, cardiac transplantation is a viable treatment
       option. AIDS has been more recently associated with IDCM. Acute left
       ventricular dysfunction and consequent dilated cardiomyopathy occur with
       increased frequency in patients with advanced AIDS. The etiology of
       dilated cardiomyopathy in HIV-infected patients is presently poorly
       understood. Survival for patients with AIDS after development of left
       ventricular dysfunction is extremely poor.
 DE    Cardiomyopathy, Congestive/*PHYSIOPATHOLOGY  Child  Child, Preschool
       Female  Human  HIV Infections/*COMPLICATIONS  Infant  Male  Pregnancy
       Pregnancy Complications, Cardiovascular/*PHYSIOPATHOLOGY  Puerperal
       Disorders/*PHYSIOPATHOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW LITERATURE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

