       Document 0863
 DOCN  M95A0863
 TI    Human immunodeficiency virus infection and genital warts as risk factors
       for anal intraepithelial neoplasia in homosexual men.
 DT    9510
 AU    Carter PS; de Ruiter A; Whatrup C; Katz DR; Ewings P; Mindel A;
       Northover JM; ICRF Colorectal Cancer Unit, St Mark's Hospital, London,
       UK.
 SO    Br J Surg. 1995 Apr;82(4):473-4. Unique Identifier : AIDSLINE
       MED/95338623
 AB    The incidence of anal intraepithelial neoplasia (AIN) was studied in a
       group of 210 homosexual and bisexual men. The presence of genital warts
       and human immunodeficiency virus (HIV) infection was assessed as risk
       factors for the development of AIN. In all, 74 (35 per cent) of the
       group had histological evidence of AIN. The relative risk of being
       positive for HIV on AIN (relative to being negative for HIV) was 1.58
       (95 per cent confidence interval (c.i.) 1.01-2.48). The relative risk of
       anal warts on AIN (relative to absence of anal warts) was 4.70 (95 per
       cent c.i. 1.81-12.20). Logistic regression analysis showed no
       significant interactive effect between HIV and anal warts on the risk of
       AIN. It is concluded from the results of a Mantel-Haenzel analysis that
       the presence of anal warts and HIV infection are independent risk
       factors for the development of AIN in homosexual and bisexual men.
 DE    Anus Diseases/*COMPLICATIONS  Anus Neoplasms/VIROLOGY  Carcinoma in
       Situ/VIROLOGY  Condylomata Acuminata/*COMPLICATIONS  *Homosexuality,
       Male  Human  HIV Infections/*COMPLICATIONS  Logistic Models  Male  Risk
       Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

