       Document 0805
 DOCN  M95A0805
 TI    Epstein-Barr virus associated lymphoproliferative disorder with fatal
       involvement of the gastrointestinal tract in an infant.
 DT    9510
 AU    Pan LX; Ramani P; Diss TC; Liang LN; Isaacson PG; Department of
       Histopathology, University College London Medical; School.
 SO    J Clin Pathol. 1995 Apr;48(4):390-2. Unique Identifier : AIDSLINE
       MED/95340909
 AB    A case of fatal Epstein-Barr virus (EBV) associated lymphoproliferative
       disorder is reported in an 11 month old female. Heavy infiltrates of
       CD20 + and EBV EBER mRNA expressing lymphoid blasts were found to cause
       a series of ulcers along the entire length of the gastrointestinal tract
       and there was an ileal perforation. Similar infiltrates were also found
       in lymph nodes, spleen, and liver. Although blood phenotypic analysis
       performed shortly before her death revealed a severe decrease in T
       lymphocytes, neither the patient nor other members of her family had a
       history of primary or secondary immunodeficiency. EBV infection is
       common in children. However, such a fatal infection of the virus has not
       apparently been described previously in infants without pre-established
       immunodeficiency.
 DE    Case Report  Fatal Outcome  Female  Gastrointestinal
       Diseases/PATHOLOGY/*VIROLOGY  Herpesviridae
       Infections/*COMPLICATIONS/PATHOLOGY  Herpesvirus 4, Human/*ISOLATION &
       PURIF  Human  Infant  Lymphoproliferative Disorders/PATHOLOGY/*VIROLOGY
       Tumor Virus Infections/*COMPLICATIONS/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

