       Document 0799
 DOCN  M95A0799
 TI    The skin as target, vector, and effector organ in human immunodeficiency
       virus disease.
 DT    9510
 AU    Blauvelt A; Katz SI; Dermatology Branch, National Cancer Institute,
       Bethesda, Maryland; 20892-1908, USA.
 SO    J Invest Dermatol. 1995 Jul;105(1 Suppl):122S-126S. Unique Identifier :
       AIDSLINE MED/95341041
 AB    Langerhans cells are CD4+ antigen-presenting cells in the dendritic cell
       family that can initiate primary and secondary immune responses after
       emigration from skin and mucosa. Because of these properties, Langerhans
       cells have been proposed as potential targets for human immunodeficiency
       virus (HIV) infection and as potential vectors for the transmission of
       primary HIV infection to T cells after mucosal exposure. In support of
       this theory, previous investigative studies have demonstrated that
       Langerhans cells are targets for HIV infection both in vivo and in vitro
       and that HIV-pulsed Langerhans cells, as well as blood dendritic cells,
       induce a productive infection in co-cultured T cells in vitro. In
       addition, Langerhans cell dysfunction has been proposed as contributing
       to the pathogenesis of some of the cutaneous manifestations observed in
       HIV+ individuals. In a recent study, we detected Langerhans cell
       dysfunction in patients with acquired immune deficiency syndrome, but
       not in earlier stages of HIV disease. Here we review previous and
       current investigative studies on HIV and the skin, with an emphasis on
       Langerhans cells, and discuss possible future investigations in this
       field.
 DE    Animal  *Disease Vectors  Human  HIV Infections/*PHYSIOPATHOLOGY
       Langerhans Cells/PHYSIOLOGY  Skin/PHYSIOPATHOLOGY/*VIROLOGY
       T-Lymphocytes, Suppressor-Effector/PHYSIOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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