       Document 0565
 DOCN  M9550565
 TI    Design of tight-binding human immunodeficiency virus type 1 protease
       inhibitors.
 DT    9505
 AU    Vacca JP; Department of Medical Chemistry, Merck Research Laboratories,;
       West Point, Pennsylvania 19486.
 SO    Methods Enzymol. 1994;241:311-34. Unique Identifier : AIDSLINE
       MED/95157318
 DE    Amino Acid Sequence  Binding Sites  Computer Simulation  Drug Design
       Gene Products, gag/CHEMISTRY  Gene Products, pol/CHEMISTRY  Hydrolysis
       HIV Protease/*CHEMISTRY/METABOLISM  HIV Protease
       Inhibitors/*CHEMISTRY/PHARMACOLOGY  HIV-1/DRUG EFFECTS/*ENZYMOLOGY
       Models, Molecular  Molecular Sequence Data
       Peptides/*CHEMISTRY/METABOLISM  Protein Binding  Protein Conformation
       Structure-Activity Relationship  Substrate Specificity  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

