       Document 0516
 DOCN  M9550516
 TI    [non-Hodgkin's lymphomas in patients with human immunodeficiency virus
       infections. Clinicopathologic characteristics, treatment response and
       prognosis in 40 patients]
 DT    9505
 AU    Ribera JM; Navarro JT; Oriol A; Raventos A; Sirera G; Flores A; Vaquero
       M; Milla F; Feliu E; Servicio de Hematologia, Hospital Universitari
       Germans Trias i; Pujol, Universidad Autonoma de Barcelona.
 SO    Sangre (Barc). 1994 Dec;39(6):429-34. Unique Identifier : AIDSLINE
       MED/95158975
 AB    BASIS: Non-Hodgkin lymphoma (NHL) is one of the commonest neoplasms
       appearing in subjects infected by the human immunodeficiency virus
       (HIV). The purpose of this work was to analyse the clinical and
       laboratory characteristics, along with the clinical course, response to
       therapy and prognosis in a series of 40 patients with NHL and HIV
       infection treated in a single institution between 1985 and 1993.
       METHODS: The following variables at onset were analysed: age, sex, risky
       behaviour, NHL location, presence of B symptoms, haemoglobin value,
       platelet count, total number of lymphocytes and CD4-positive lymphocyte
       count, erythrocyte sedimentation rate, LDH levels, serum albumin, beta
       2-microglobulin, NHL type and staging. The following variables during
       follow-up were also examined: treatment administered, achievement of
       remission and remission duration, date of relapse and death or date of
       the last control, relapse-free survival (RFS) and overall survival (OS).
       A multivariate study of the prognostic factors associated to the
       achievement of remission, RFS and OS were carried out as well. RESULTS:
       The frequency of NHL amongst the HIV-positive subjects was 4.4%. Thirty
       cases had high-grade lymphoma, 20 were stage IV and 33 had extranodal
       locations. Anaemia was the commonest blood impairment and CD4-positive
       lymphocyte count was below 0.2 x 10(9)/L in 72% of the cases.
       Twenty-eight patients with systemic NHL received chemotherapy (CHOP in
       25 instances, MACOP-B in 3), and of them 6 were alive, 5 in maintained
       remission, as for this paper's writing. The median RFS was 7 months and
       the median OS was 11 months. Increased serum LDH was associated with
       lesser probability of attaining both remission (p = 0.03) and RFS (p =
       0.03). Response to therapy was the main factor in determining survival
       (p = 0.002); after excluding such factor, increased serum LDH and low
       serum albumin rates correlated negatively with OS (p = 0.004 and p =
       0.007, respectively). CONCLUSIONS: HIV-positive patients, when affected
       by NHL, usually have high-grade lymphoma, frequently in advanced stages
       and with extra-nodal involvement. They show poor response to therapy.
       Increased serum LDH level is the main prognostic factor.
 DE    Adult  English Abstract  Female  Human  Lymphoma,
       AIDS-Related/BLOOD/*EPIDEMIOLOGY/MORTALITY/PATHOLOGY  Lymphoma,
       Non-Hodgkin's/BLOOD/*EPIDEMIOLOGY/MORTALITY/PATHOLOGY  Male  Middle Age
       Neoplasm Staging  Spain/EPIDEMIOLOGY  Substance Abuse,
       Intravenous/COMPLICATIONS  Support, Non-U.S. Gov't  Survival Analysis
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

