       Document 0811
 DOCN  M9460811
 TI    Radiation therapy for non-AIDS associated (classic and endemic African)
       and epidemic Kaposi's sarcoma.
 DT    9404
 AU    Stein ME; Lakier R; Spencer D; Dale J; Kuten A; MacPhail P; Bezwoda WR;
       Department of Medical Oncology and Hematology, University of the;
       Witwatersrand, Johannesburg, Republic of South Africa.
 SO    Int J Radiat Oncol Biol Phys. 1994 Feb 1;28(3):613-9. Unique Identifier
       : AIDSLINE MED/94156755
 AB    PURPOSE: A retrospective analysis of patients with non-AIDS and
       AIDS-related Kaposi's sarcoma, who were treated with radiation therapy.
       METHODS AND MATERIALS: Between 1978 and 1992, 56 patients with one of
       the three major types (classical, endemic, epidemic) of Kaposi's sarcoma
       received radiation therapy as their sole treatment modality. Extent of
       fields, daily fractionation, and total dose were applied on a clinical
       basis. These lesions received superficial x-ray therapy, Co-60
       teletherapy, or 6-8 MeV electron beams. Field sizes depended on extent
       of the lesion. Total dose administration ranged from 8-12 Gy in one
       exposure, or a total of 24-30 Gy fractionated over 2-3 weeks. RESULTS:
       The majority of patients responded to radiation therapy. Symptomatic
       relief was achieved in 80-100% of patients irrespective of the type of
       Kaposi's sarcoma, treatment modality, or schedule. Side effects were
       tolerable in all but three patients with epidemic type Kaposi's sarcoma,
       who developed severe mucositis. CONCLUSION: Radiotherapy is the most
       useful mode of palliative treatment for all forms of Kaposi's sarcoma in
       southern African patients.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/EPIDEMIOLOGY  Adult
       Africa/EPIDEMIOLOGY  Aged  Aged, 80 and over  Female  Follow-Up Studies
       Human  Male  Middle Age  Retrospective Studies  Sarcoma,
       Kaposi's/EPIDEMIOLOGY/ETIOLOGY/*RADIOTHERAPY  JOURNAL ARTICLE  REVIEW
       REVIEW LITERATURE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

