       Document 0763
 DOCN  M9460763
 TI    [Blood donation by relatives in pediatrics]
 DT    9404
 AU    Gottsche B; Mueller-Eckhardt C; Zentrum fur Kinderheilkunde,
       Justus-Liebig-Universitat,; Giessen.
 SO    Monatsschr Kinderheilkd. 1993 Dec;141(12):914-9; quiz 920-1, 954-5.
       Unique Identifier : AIDSLINE MED/94158916
 AB    Directed blood donations from family members are frequently desired for
       pediatric patients. A reduced risk for transfusion-transmitted diseases
       could not be proved. There are indications that recommendation of
       directed blood donation could oblige members of risk groups for HIV or
       hepatitis infection to donate blood since their voluntariness is not
       guaranteed and the possibility of self-exclusion is omitted. In some
       instances it may be necessary to perform directed blood donations from
       relatives because of immunological or medical principles, e.g.
       transfusion of maternal platelets in neonatal alloimmune
       thrombocytopenia. In contrast, directed blood donations should not be
       realized for most hematologic-oncologic patients because they bear the
       risk of immunisation against alloantigens of the donor and can thus
       prevent a later bone marrow transplantation from relatives. Inspite of
       reservations against directed blood donations for individual cases the
       pediatrician and the transfusion medicine service will have to decide on
       blood donations from relatives. In any case the blood products should be
       irradiated with 30 Gy to avoid a transfusion-related
       graft-versus-host-reaction.
 DE    Adolescence  *Blood Donors  Blood Group Incompatibility/BLOOD/PREVENTION
       & CONTROL  *Blood Transfusion  Blood-Borne Pathogens  Child  Child,
       Preschool  English Abstract  Graft vs Host Reaction  Human  Infant
       Infant, Newborn  Risk Factors  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

