       Document 0725
 DOCN  M9460725
 TI    Cerebrospinal fluid-intracranial volume ratio measurements in patients
       with HIV infection: CLASS image analysis technique.
 DT    9404
 AU    Paley MN; Chong WK; Wilkinson ID; Shepherd JK; Clews AM; Sweeney BJ;
       Hall-Craggs MA; Kendall BE; Newman SP; Harrison MJ; Department of
       Neurology, University College London Medical School; and Middlesex
       Hospital, England.
 SO    Radiology. 1994 Mar;190(3):879-86. Unique Identifier : AIDSLINE
       MED/94159891
 AB    PURPOSE: To prospectively study the cerebrospinal fluid volume-total
       intracranial volume ratio (CSF/ICV) in human immunodeficiency virus
       (HIV)-infected patients at various stages of disease. MATERIALS AND
       METHODS: A total of 258 volume measurements were obtained with use of a
       1.5-T magnetic resonance (MR) imager and the cluster localized automated
       spherical segmentation technique (which reduces two-dimensional pixel
       data from dual spin-echo MR images to a one-dimensional histogram) in 69
       control subjects and 189 HIV-infected patients. RESULTS: The CSF/ICV was
       statistically significantly increased in patients with late-stage
       (Centers for Disease Control and Prevention group IV) acquired
       immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation])
       compared with seronegative control subjects (0.12 +/- 0.03) and patients
       without symptoms (0.13 +/- 0.03). CONCLUSION: No substantial change in
       CSF/ICV occurs until development of late-stage AIDS.
 DE    Acquired Immunodeficiency Syndrome/CEREBROSPINAL FLUID/*DIAGNOSIS/
       EPIDEMIOLOGY  Adult  Atrophy  Brain/*PATHOLOGY  Comparative Study
       Homosexuality  Human  HIV Seronegativity  HIV Seropositivity  *Image
       Processing, Computer-Assisted  Magnetic Resonance Imaging/*METHODS  Male
       Models, Structural  Prospective Studies  Risk Factors  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

