       Document 0685
 DOCN  M9460685
 TI    In situ characterization of leukocytes in the fallopian tube in women
       with or without an intrauterine contraceptive device.
 DT    9404
 AU    Wollen AL; Sandvei R; Mork S; Marandon JL; Matre R; Institute of Anatomy
       and Cell Biology, Gade Institute, University; of Bergen, Norway.
 SO    Acta Obstet Gynecol Scand. 1994 Feb;73(2):103-12. Unique Identifier :
       AIDSLINE MED/94160703
 AB    Histological evaluation of sections from the human fallopian tube
       revealed an inflammatory reaction in 21 of 31 women using an
       intrauterine contraceptive device (IUCD) and in four of 29 controls
       (non-IUCD users). The inflammatory cells were mainly localized at the
       epithelium-lamina propria interface and at the center of the mucosal
       folds. The immunohistochemical study revealed leukocytes (CD45+), T
       lymphocytes (CD3+), T helper cells (CD4+), T suppressor/cytotoxic cells
       (CD8+), B lymphocytes (CD22+, CD19+), granulocytes, monocytes and null
       cells (CD11b+) mainly localized at the lamina propria in both groups. T
       lymphocytes were the predominant cell type, and the ratio between T
       helper and T suppressor/cytotoxic cells was fairly close to one both in
       IUCD-users and controls. B lymphocytes were the least frequent cell type
       identified. In IUCD users, the numbers of the different leukocytes were
       increased. In both groups, IgA-, IgG- and IgM-positive cells were
       demonstrated and were predominantly located at the lamina propria of the
       mucosal folds. The IgA-positive cells dominated in both groups, whereas
       IgG- and IgM-positive cells were less frequent. Cell positive for IgA,
       IgG or IgM were significantly increased in number in the IUCD users. The
       data confirm the presence of an immune system in the normal human
       fallopian tube and indicate that the IUCD can induce a prominent
       recruitment of inflammatory cells, with a tubal inflammation as the
       result. The IUCD may disturb the immunological function of the fallopian
       tube and its role in fertilization.
 DE    Adult  Antigens, CD45/ANALYSIS  Biopsy  CD4-CD8 Ratio  Fallopian
       Tubes/IMMUNOLOGY/*PATHOLOGY  Female  Fibrosis  Human
       Immunoglobulins/ANALYSIS  Immunohistochemistry  Intrauterine Devices,
       Copper/*ADVERSE EFFECTS  Leukocyte Count
       Leukocytes/IMMUNOLOGY/*PATHOLOGY  Middle Age
       Salpingitis/ETIOLOGY/IMMUNOLOGY/*PATHOLOGY  Sterilization, Tubal
       Support, Non-U.S. Gov't  T-Lymphocytes/IMMUNOLOGY/PATHOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

