       Document 0531
 DOCN  M9460531
 TI    Bile acid malabsorption in AIDS-associated chronic diarrhea: a
       prospective 1-year study.
 DT    9404
 AU    Sciarretta G; Bonazzi L; Monti M; Furno A; Mazzoni M; Mazzetti M; Gritti
       F; Malaguti P; Department of Gastroenterology, Ospedale Maggiore,
       Bologna,; Italy.
 SO    Am J Gastroenterol. 1994 Mar;89(3):379-81. Unique Identifier : AIDSLINE
       MED/94168175
 AB    OBJECTIVES: In patients with chronic diarrhea associated with acquired
       immunodeficiency syndrome, bile acid malabsorption, very rarely
       investigated, may have an important pathogenetic role. METHODS: In this
       1-yr prospective study, 15 patients with AIDS-associated chronic
       diarrhea and 10 AIDS-controls were studied for bile acid malabsorption
       by means of the SeHCAT abdominal retention test. The patients with
       diarrhea underwent the glucose hydrogen breath test to identify any
       bacterial proliferation in the small bowel. RESULTS: In the chronic
       diarrhea group, only one case of small bowel bacterial overgrowth, and
       seven cases (47%) with generally severe bile acid malabsorption, were
       observed. Among the controls, only one had an abnormal low SeHCAT
       retention. In both cases with Cryptosporidium infection, the SeHCAT test
       was pathological. CONCLUSIONS: These data are of clinical importance for
       the pathogenetic study of AIDS-associated chronic diarrhea and for
       specific treatment with cholestyramine.
 DE    Adult  AIDS-Related Opportunistic Infections/*COMPLICATIONS/EPIDEMIOLOGY
       Bile Acids and Salts/*METABOLISM  Breath Tests
       Cryptosporidiosis/*COMPLICATIONS/EPIDEMIOLOGY
       Diarrhea/*COMPLICATIONS/EPIDEMIOLOGY  Female  Human  Malabsorption
       Syndromes/*COMPLICATIONS/EPIDEMIOLOGY  Male  Prevalence  Prospective
       Studies  Selenium Radioisotopes/DIAGNOSTIC USE  Taurocholic Acid/ANALOGS
       & DERIVATIVES/DIAGNOSTIC USE  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

