       Document 0517
 DOCN  M9460517
 TI    Immunomodifiers applicable to the prevention and management of
       infectious diseases in children.
 DT    9404
 AU    La Pine TR; Hill HR; Department of Pediatrics, University of Utah School
       of Medicine,; Salt Lake City.
 SO    Adv Pediatr Infect Dis. 1994;9:37-58. Unique Identifier : AIDSLINE
       MED/94168668
 AB    Attempts to augment immune function in infants or children with
       overwhelming sepsis or immune deficiency have focused on recombinant
       cytokines and interferons. Although early in their clinical use, the
       proinflammatory and antiinflammatory effects of the interleukins show
       promise in regulating the acute inflammatory response. The hematopoietic
       growth factors have demonstrated considerable clinical effect,
       especially in individuals with distinct hematopoietic disorders and in
       patients receiving immunosuppressive chemotherapy. The interferons gamma
       and alpha have received considerable attention over the last decade as
       potential immunomodulators. The stimulatory effects of INF-gamma on
       human neutrophils suggest its therapeutic usefulness in children with
       specific neutrophil dysfunction, and INF-alpha has shown broad clinical
       application both as an antitumor as well as an antiviral agent. The most
       recent studies of the integrins and selectins implicate their potential
       role in regulating a number of infectious disease states. As we learn
       more about the complexity of interactions and the delicate balance these
       molecules have in regulating the immune response, we will be better able
       to implement their use in regulating disease states in infants and
       children.
 DE    AIDS-Related Opportunistic Infections/PREVENTION & CONTROL  Child
       Child, Preschool  Colony-Stimulating Factors/THERAPEUTIC USE
       Cytokines/*THERAPEUTIC USE  Human  Infant  Infection/*DRUG
       THERAPY/IMMUNOLOGY  Integrins  Interferon Type II/THERAPEUTIC USE
       Interferon-alpha/THERAPEUTIC USE  Platelet Membrane
       Glycoproteins/THERAPEUTIC USE  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

