       Document 0497
 DOCN  M9460497
 TI    Neuropathology of AIDS in surgical biopsy specimens.
 DT    9404
 AU    Miller DC; Najjar S; Budzilovich GN; New York University School of
       Medicine and Medical Center, New; York.
 SO    Neurosurg Clin N Am. 1994 Jan;5(1):57-70. Unique Identifier : AIDSLINE
       MED/94169649
 AB    In this brief review of the surgical neuropathology of AIDS we have
       emphasized that, although there are obvious and meaningful similarities
       between the autopsy descriptions of AIDS-related CNS disease and those
       we have seen in surgical specimens, there are also some clear
       differences in terms of which types of lesions are likely to undergo
       biopsy. It is also clear that the smaller samples allowed by
       neurosurgical procedures, particularly in stereotaxic biopsies, can
       limit the expression of the full pathologic pattern of these entities as
       expected from autopsy evaluations. Nevertheless, useful diagnostic
       information is readily and routinely obtained when the surgical sampling
       is carefully planned and when the tissues obtained are properly handled.
       There is a role, however, a limited one, for frozen sections in
       intraoperative consultations. The best diagnostic study is a careful
       perusal of a good hematoxylin and eosin stain, but judicious use of
       histochemical and immunohistochemical methods can be essential to a
       proper diagnosis in selected cases.
 DE    Adult  AIDS Dementia Complex/*PATHOLOGY/SURGERY  AIDS-Related
       Opportunistic Infections/*PATHOLOGY  Biopsy, Needle
       Brain/PATHOLOGY/SURGERY  Brain Diseases/*PATHOLOGY/SURGERY  Brain
       Neoplasms/PATHOLOGY/SURGERY  Case Report  Disease Transmission,
       Patient-to-Professional  Female  Frozen Sections  Human  *HIV-1
       Lymphoma, AIDS-Related/PATHOLOGY/SURGERY  Male  Middle Age  Universal
       Precautions  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

