       Document 0355
 DOCN  M9460355
 TI    Increased antiretroviral antibody reactivity in sera from a defined
       population of patients with systemic lupus erythematosus. Correlation
       with autoantibodies and clinical manifestations.
 DT    9404
 AU    Blomberg J; Nived O; Pipkorn R; Bengtsson A; Erlinge D; Sturfelt G;
       Department of Medical Microbiology, University of Lund, Sweden.
 SO    Arthritis Rheum. 1994 Jan;37(1):57-66. Unique Identifier : AIDSLINE
       MED/94175947
 AB    OBJECTIVE. The implied role of retroviruses in the pathogenesis of
       murine systemic lupus erythematosus (SLE) led us to study antiretroviral
       antibodies in a population-based SLE cohort. METHODS. Immunoassays using
       whole virus and synthetic peptides were performed on sera from 72
       patients with SLE and 88 control subjects. RESULTS. Reactions with whole
       baboon endogenous virus occurred more frequently in patients with SLE,
       and correlated with the presence of anti-RNP and anti-Sm. Some
       retroviral env and gag peptides, several of which were similar to U1
       small nuclear RNP, reacted more strongly in patients with SLE, and their
       presence was correlated with discoid rash, hematologic disorder, and
       other symptoms. CONCLUSION. These results provide circumstantial
       evidence for involvement of retroviruses in the pathogenesis of human
       SLE; further studies should be carried out using other techniques for
       measurement of retroviral expression.
 DE    Adult  Amino Acid Sequence  Animal  Antibodies, Viral/*BLOOD  Antigenic
       Determinants  Autoimmunity  Biological Markers/ANALYSIS  Cross Reactions
       Female  Human  Immunoenzyme Techniques  Lupus Erythematosus,
       Systemic/*BLOOD  Male  Middle Age  Molecular Sequence Data
       Retroviridae/*IMMUNOLOGY  Retroviridae Proteins/BLOOD/IMMUNOLOGY
       Retroviruses, MLV-Related/IMMUNOLOGY  Retroviruses, Simian/IMMUNOLOGY
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

