       Document 0312
 DOCN  M9460312
 TI    Outbreak of Chlamydia pneumoniae infection in former injection-drug
       users.
 DT    9404
 AU    Blasi F; Boschini A; Cosentini R; Legnani D; Smacchia C; Ghira C;
       Allegra L; Institute of Respiratory Diseases, University of Milan,
       Italy.
 SO    Chest. 1994 Mar;105(3):812-5. Unique Identifier : AIDSLINE MED/94178007
 AB    In a retrospective analysis of lower respiratory tract infections in an
       ex-injection-drug users community, we found an outbreak (April to July
       1991) of Chlamydia pneumoniae infection. The epidemic occurred in a
       group of 26 community members (23 men and 3 women, mean age, 28.9--3
       years) living and working together, who underwent acute and convalescent
       serologic tests for Mycoplasma pneumoniae, Legionella pneumophila,
       cytomegalovirus, adenovirus, Coxiella burnetii, and Chlamydia
       pneumoniae. All subjects were submitted to chest radiograph, while
       sputum and blood cultures were performed in symptomatic patients.
       Antibodies to C pneumoniae were determined by a microimmunofluorescence
       test. Among all subjects studied (13 HIV-1 positive and 13 HIV-1
       negative), 11 (8 HIV-positive and 3 HIV-negative) developed pneumonia, 2
       (1 HIV-positive and 1 HIV-negative) developed pharyngitis, and 2 (1 HIV-
       positive and 1 HIV-negative) developed flu-like syndromes sustained by C
       pneumoniae; in 4 subjects (2 HIV-positive and 2 HIV-negative) suffering
       from flu-like syndrome, no causal agents were found. Seven subjects (one
       HIV-positive and six HIV- negative) remained asymptomatic without any
       evidence of infection. The prevalence of antibodies to C pneumoniae in
       HIV-1-positive subjects observed in a sample of community members was
       significantly higher than in HIV-1-negative subjects. C pneumoniae seems
       to be involved in respiratory tract infections in HIV-1-infected
       subjects. Our data suggest that C pneumoniae should be included in the
       diagnostic approach of respiratory infections in HIV-infected subjects.
 DE    Adult  AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/MICROBIOLOGY
       Chlamydia pneumoniae/*ISOLATION & PURIF  Chlamydia
       Infections/*EPIDEMIOLOGY  *Disease Outbreaks  Female  Human  HIV
       Seronegativity  HIV Seropositivity  Male
       Pneumonia/EPIDEMIOLOGY/*MICROBIOLOGY  Prevalence  Retrospective Studies
       *Substance Abuse Treatment Centers  *Substance Abuse, Intravenous
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

