       Document 0180
 DOCN  M9460180
 TI    Pneumocystis carinii pneumonia in vertically acquired HIV infection in
       the British Isles.
 DT    9404
 AU    Gibb DM; Davison CF; Holland FJ; Walters S; Novelli V; Mok J; Department
       of Epidemiology and Biostatistics, Institute of Child; Health, London.
 SO    Arch Dis Child. 1994 Mar;70(3):241-4. Unique Identifier : AIDSLINE
       MED/94182976
 AB    In order to review the clinical course, laboratory findings, and outcome
       of children with vertically acquired HIV infection and Pneumocystis
       carinii pneumonia, questionnaires were sent to paediatricians in the
       British Isles who had reported P carinii pneumonia and HIV infection
       through the British Paediatric Surveillance Unit (BPSU). Paediatric
       reports from the BPSU are linked to reports of pregnancies in HIV
       positive women and laboratory reports. P carinii pneumonia was the most
       frequently reported AIDS indicator disease at AIDS diagnosis, occurring
       in 22/56 (40%) children born in the British Isles; in a further two
       children P carinii pneumonia occurred after another AIDS indicator
       disease. The median age at P carinii pneumonia diagnosis was 4.1
       (1.4-27.3) months and in 48% it occurred with other AIDS indicator
       diseases. Despite intensive treatment the three month survival was only
       38%. The nine children surviving P carinii pneumonia subsequently
       developed further AIDS indicator diseases, in particular HIV
       encephalopathy and four have since died. P carinii pneumonia was present
       at AIDS diagnosis in 65% of children developing AIDS in the first year
       of life and caused 82% of infant deaths. Most children were not known to
       be at risk of HIV until they presented with P carinii pneumonia.
       Children with HIV infection develop P carinii pneumonia at an early age
       and have a poor outcome. Increased awareness of the condition is
       required to initiate early treatment. Prevention may be a compelling
       incentive for screening in pregnancy, but further study is required to
       quantify the risks and benefits of initiating early P carinii pneumonia
       prophylaxis as well as the impact this might have on life expectancy.
 DE    Acquired Immunodeficiency Syndrome/MORTALITY/TRANSMISSION  Age Factors
       AIDS Dementia Complex/MORTALITY  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS  Child  Child, Preschool  Female  Great
       Britain/EPIDEMIOLOGY  Human  Infant  Pneumonia, Pneumocystis
       carinii/*DIAGNOSIS/MORTALITY  Prognosis  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

