       Document 0150
 DOCN  M9460150
 TI    Abnormalities in subset distribution, activation, and differentiation of
       T cells isolated from large intestine biopsies in HIV infection. The
       Berlin Diarrhoea/Wasting Syndrome Study Group.
 DT    9404
 AU    Schneider T; Ullrich R; Bergs C; Schmidt W; Riecken EO; Zeitz M;
       Department of Medicine, Klinikum Steglitz, Free University of; Berlin,
       Germany.
 SO    Clin Exp Immunol. 1994 Mar;95(3):430-5. Unique Identifier : AIDSLINE
       MED/94185311
 AB    Intestinal T cells have a unique state of activation and differentiation
       which might specifically affect or be affected by HIV infection.
       Lymphocyte subsets in the peripheral blood are well characterized, but
       our knowledge about intestinal lymphocytes in HIV infection is
       incomplete. We therefore analysed lymphocytes isolated from large
       intestine biopsies of AIDS patients and controls by three-colour
       cytofluorometry. In the large intestine of HIV-infected patients CD4 T
       cells were reduced and CD8 T cells were increased compared with
       controls. Most of the CD8 T cells in the colorectal mucosa of AIDS
       patients were of the cytotoxic phenotype. Activated and resting CD4 T
       cells were similarly reduced, the expression of CD25 and HLA-DR of CD8 T
       cells was unaltered and increased, respectively. In intestinal CD4 T
       cells the expression of CD29 was decreased, but the expression of CD45RO
       and HML-1 was normal. CD8 T cells had a decreased expression of all
       these differentiation markers. Our findings demonstrate substantial
       alterations in subset distribution, activation, and differentiation of
       large intestine T cells, which may contribute to the secondary
       infections and malignancies commonly observed in the gut of AIDS
       patients.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Adult  Antigens,
       CD/ANALYSIS  B-Lymphocytes  Cell Differentiation  Female  Flow Cytometry
       Fluorometry  Human  HLA-DR Antigens/ANALYSIS  Integrins/ANALYSIS
       Intestine, Large/*IMMUNOLOGY  Killer Cells, Natural  *Lymphocyte
       Transformation  Male  Middle Age  Support, Non-U.S. Gov't  *T-Lymphocyte
       Subsets  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

