       Document 0149
 DOCN  M9460149
 TI    Selective increase of activation antigens HLA-DR and CD38 on CD4+
       CD45RO+ T lymphocytes during HIV-1 infection.
 DT    9404
 AU    Kestens L; Vanham G; Vereecken C; Vandenbruaene M; Vercauteren G;
       Colebunders RL; Gigase PL; Laboratory of Pathology & Immunology,
       Institute of Tropical; Medicine, Antwerpen, Belgium.
 SO    Clin Exp Immunol. 1994 Mar;95(3):436-41. Unique Identifier : AIDSLINE
       MED/94185312
 AB    Infection with HIV results in a progressive depletion of CD4+ T cells
       and leads to significant in vivo lymphocyte phenotype changes. In this
       regard, the expression of HLA-DR and CD38 on CD8+ T cells has been shown
       to increase dramatically with disease progression. We investigated the
       expression of both activation markers on CD4+ T cells in HIV-1-infected
       subjects at different clinical stages of infection and compared the in
       vivo activation of CD4+ T cells with parameters of viral activity and
       CD8+ T cell activation. Fresh peripheral venous blood was obtained from
       54 HIV-infected subjects and from 28 uninfected healthy controls.
       Three-colour immunophenotyping of the CD4+ T cell subset showed that the
       proportion of CD4+ T cells expressing HLA-DR (10% in HIV-negative
       controls) or CD38 (62% in HIV-negative controls) was higher in
       asymptomatic (P < 0.05 for CD38) and symptomatic (P < 0.001 for HLA-DR
       and CD38) HIV-infected subjects than in controls, whereas the proportion
       of CD4+ T cells expressing CD45RO (54% in controls) remained relatively
       unchanged. Simultaneous expression of HLA-DR and CD38 on CD4+ T cells
       increased from 2.3% in controls to 11% (P < 0.001) in asymptomatic and
       22% (P < 0.001) in symptomatic HIV-infected subjects. This relative
       increase of CD38 and HLA-DR expression occurred mainly on CD4+ T cells
       co-expressing CD45RO. Changes in expression of HLA-DR and CD38 on CD4+ T
       cells correlated with similar changes on CD8+ T lymphocytes, with the
       presence of HIV antigen in the circulation, and with the disease stage
       of HIV infection.
 DE    Adult  *Antigens, CD45  Antigens, CD8  Antigens,
       Differentiation/*ANALYSIS  Antiviral Agents/THERAPEUTIC USE  Comparative
       Study  Female  Human  HIV Infections/DRUG THERAPY/*IMMUNOLOGY  HLA-DR
       Antigens/*ANALYSIS  Immunophenotyping  Male  T4 Lymphocytes/*IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

