       Document 0146
 DOCN  M9460146
 TI    Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear
       cells; correlation with the induction of other cytokines.
 DT    9404
 AU    Ameglio F; Capobianchi MR; Castilletti C; Cordiali Fei P; Fais S; Trento
       E; Dianzani F; Institute S. Gallicano, University La Sapienza, Rome,
       Italy.
 SO    Clin Exp Immunol. 1994 Mar;95(3):455-8. Unique Identifier : AIDSLINE
       MED/94185315
 AB    Immunological abnormalities present in HIV-1-infected individuals often
       reflect an imbalance of cytokine production. The HIV-1 gp120 has the
       ability to induce a number of cytokines, and to enhance immunoglobulin
       release by normal peripheral blood mononuclear cells (PBMC) in vitro, in
       the absence of IL-2 production and of lymphoproliferation. This study
       provides evidence that gp120 is a potent IL-10 inducer in normal PBMC
       cultures. The pattern of other cytokines induced by gp120 includes
       interferon-alpha (IFN-alpha) and IFN-gamma, tumour necrosis factor-alpha
       (TNF-alpha), IL-6, IL-1 alpha and -beta, and not IL-2 and IL-4. These
       findings further define the pattern of cytokine release induced by gp120
       on human resting PBMC. Furthermore, the present findings roughly
       parallel those observed both in the sera of patients and in the
       mononuclear cells from HIV+ individuals early after infection,
       suggesting that gp120 could be a good candidate as one of the agents
       responsible for cytokine dysregulation observed in HIV-1-infected
       individuals.
 DE    Biopterin/ANALOGS & DERIVATIVES/BIOSYNTHESIS  Cytokines/*BIOSYNTHESIS
       Human  HIV Envelope Protein gp120/*PHARMACOLOGY
       Interferons/BIOSYNTHESIS  Interleukin-10/*BIOSYNTHESIS
       Interleukins/BIOSYNTHESIS  Leukocytes, Mononuclear/*DRUG EFFECTS
       Recombinant Proteins/PHARMACOLOGY  Support, Non-U.S. Gov't  Tumor
       Necrosis Factor/BIOSYNTHESIS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

