       Document 0143
 DOCN  M9460143
 TI    The development of the immune system--importance in the ascertainment of
       immunophenotypic changes in perinatal HIV infection.
 DT    9404
 AU    Nahmias A; Ibegbu C; Lee F; Spira T; Department of Pediatrics, Emory
       University School of Medicine,; Atlanta, Georgia 30303.
 SO    Clin Immunol Immunopathol. 1994 Apr;71(1):2-7. Unique Identifier :
       AIDSLINE MED/94185334
 AB    Evidence is presented that the percentage and number of some subsets of
       T and B cells in normal children and adults vary greatly from those in
       fetal life and throughout the first few years after birth, and less so
       during adolescence and adulthood. Depending then on the age at which
       immunological studies are performed, as well as whether the HIV
       infection occurs in utero, at birth, or postnatally, values obtained by
       immunophenotypic analyses of differentiating or mature immunocytes will
       vary greatly. A concerted effort needs to be made to measure different
       developmental and activation immunophenotypic markers, from birth on, in
       premature and full-term infants of varying socioeconomic and ethnic
       background. Results from such studies should improve our ability to
       determine the timing of HIV infection, to obtain earlier guidelines for
       prophylaxis or treatment of the virus or of opportunistic infections, as
       well as to improve prognostic capabilities in perinatal HIV infection.
 DE    Fetus/IMMUNOLOGY  Human  HIV Infections/*CONGENITAL  Immune
       System/EMBRYOLOGY/*GROWTH & DEVELOPMENT  Immunophenotyping  Infant
       Infant, Newborn  Support, U.S. Gov't, P.H.S.  T-Lymphocyte
       Subsets/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

