       Document 0085
 DOCN  M9460085
 TI    [Successful treatment of chemotherapy-resistant adult T cell
       leukemia/lymphoma by irinotecan hydrochloride (CPT-11)]
 DT    9404
 AU    Makino T; Nakahara K; Takatsuka Y; Shimotakahara S; Utsunomiya A; Hanada
       S; Tokunaga M; Arima T; Second Dept. of Internal Medicine, Faculty of
       Medicine, Kagoshima; University.
 SO    Rinsho Ketsueki. 1994 Jan;35(1):42-8. Unique Identifier : AIDSLINE
       MED/94187172
 AB    A 62-year-old man was hospitalized in March 1990 due to upper abdominal
       discomfort and anorexia. The chest X-ray revealed an upper anterior
       mediastinal tumor, and abdominal ultrasound showed lymphadenopathy.
       Endoscopic examination of the stomach revealed a large, irregular ulcer,
       which was histologically confirmed to be malignant lymphoma by biopsy.
       Serum anti-HTLV-1 antibody was positive. A diagnosis of ATLL (lymphoma
       type) was made. The usual therapy for this disease, including the LSG4
       and RCM protocols, was only transiently effective. Therefore, the
       patient was treated with CPT-11 (40 mg/m2) by intravenous infusion on 3
       consecutive days with weekly repetition in November 1990. Complete
       remission was obtained after 2 weeks of treatment, and was maintained
       for 5 months. This case suggests that CPT-11 may be effective for the
       treatment of ATL.
 DE    Aged  Antineoplastic Agents, Combined/THERAPEUTIC USE  Antineoplastic
       Agents, Phytogenic/*ADMINISTRATION & DOSAGE  Camptothecin/*ANALOGS &
       DERIVATIVES/ADMINISTRATION & DOSAGE  Case Report  Drug Resistance
       English Abstract  Human  Infusions, Intravenous  Leukemia-Lymphoma,
       T-Cell, Acute, HTLV-I-Associated/*DRUG THERAPY  Male  Remission
       Induction  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

