       Document 0020
 DOCN  M9460020
 TI    SPECT imaging of the brain: comparison of findings in patients with
       chronic fatigue syndrome, AIDS dementia complex, and major unipolar
       depression.
 DT    9404
 AU    Schwartz RB; Komaroff AL; Garada BM; Gleit M; Doolittle TH; Bates DW;
       Vasile RG; Holman BL; Department of Radiology, Brigham and Women's
       Hospital, Boston, MA; 02215.
 SO    AJR Am J Roentgenol. 1994 Apr;162(4):943-51. Unique Identifier :
       AIDSLINE MED/94189428
 AB    OBJECTIVE. Chronic fatigue syndrome is an illness of unknown origin that
       begins abruptly with a flulike state and has symptoms suggesting both a
       chronic viral encephalitis and an affective disorder. We compared
       single-photon emission computed tomography (SPECT) scans of patients
       with chronic fatigue syndrome with those of patients with AIDS dementia
       complex and unipolar depression. SUBJECTS AND METHODS. We used
       99mTc-hexamethylpropyleneamine oxime to examine 45 patients with chronic
       fatigue syndrome, 27 patients with AIDS dementia complex, and 14
       patients with major unipolar depression. Scans of 38 healthy persons
       were used as controls. Comparison of regional defects between groups, as
       well as midcerebral uptake indexes (an objective measure of global
       radionuclide uptake), was performed by using analysis of variance with
       the Student-Newman-Keuls option. Correlation between the number of
       regional defects and the midcerebral uptake index was determined by
       using the Spearman rank-correlation test. RESULTS. Patients with AIDS
       dementia complex had the largest number of defects (9.15 per patient)
       and healthy patients had the fewest defects (1.66 per patient). Patients
       with chronic fatigue syndrome and depression had similar numbers of
       defects per patient (6.53 and 6.43, respectively). In all groups,
       defects were located predominantly in the frontal and temporal lobes.
       The midcerebral uptake index was found to be significantly lower (p <
       .002) in the patients with chronic fatigue syndrome (.667) and patients
       with AIDS dementia complex (.650) than in patients with major depression
       (.731) or healthy control subjects (.716). Also, a significant negative
       correlation was found between the number of defects and midcerebral
       uptake index in patients with chronic fatigue syndrome and AIDS dementia
       complex, but not in depressed patients or control subjects. CONCLUSION.
       These findings are consistent with the hypothesis that chronic fatigue
       syndrome may be due to a chronic viral encephalitis; clinical
       similarities between chronic fatigue syndrome and depression may be due
       to a similar distribution and number of defects in the two disorders.
 DE    Adult  Aged  AIDS Dementia Complex/*RADIONUCLIDE IMAGING
       Brain/*RADIONUCLIDE IMAGING  Comparative Study  Depressive
       Disorder/*RADIONUCLIDE IMAGING  Fatigue Syndrome,
       Chronic/ETIOLOGY/*RADIONUCLIDE IMAGING  Female  Human  Male
       Organotechnetium Compounds/DIAGNOSTIC USE  Oximes/DIAGNOSTIC USE
       Support, U.S. Gov't, P.H.S.  *Tomography, Emission-Computed,
       Single-Photon  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

